Q
Qiqiang Guo
Researcher at China Medical University (PRC)
Publications - 20
Citations - 283
Qiqiang Guo is an academic researcher from China Medical University (PRC). The author has contributed to research in topics: Autophagy & Medicine. The author has an hindex of 6, co-authored 13 publications receiving 116 citations.
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Journal ArticleDOI
ATM-CHK2-Beclin 1 axis promotes autophagy to maintain ROS homeostasis under oxidative stress.
Qiqiang Guo,Shan-Shan Wang,Shan-Shan Zhang,Hongde Xu,Xiaoman Li,Yi Guan,Fei Yi,Tingting Zhou,Bo Jiang,Ning Bai,Meng-Tao Ma,Zhuo Wang,Yanling Feng,Wendong Guo,Xuan Wu,Gui-Feng Zhao,Guangjian Fan,Shengping Zhang,Chuangui Wang,Longyue Cao,Brian P. O’Rourke,Shihui Liu,Ping-Yuan Wang,Shuai Han,Xiaoyu Song,Liu Cao +25 more
TL;DR: The results indicate that the ROS‐ATM‐CHK2‐Beclin 1‐autophagy axis serves as a physiological adaptation pathway that protects cells exposed to pathological conditions from stress‐induced tissue damage.
Journal ArticleDOI
SIRT1 modulates cell cycle progression by regulating CHK2 acetylation−phosphorylation
Wenyu Zhang,Yanling Feng,Qiqiang Guo,Wendong Guo,Hongde Xu,Xiaoman Li,Fei Yi,Yi Guan,Nanxi Geng,Ping-Yuan Wang,Longyue Cao,Brian P. O’Rourke,Juhyeon Jo,Jiyun Kwon,Ruihong Wang,Xiaoyu Song,In Hye Lee,Liu Cao +17 more
TL;DR: It is suggested that CHK2 mediates the function of SIRT1 in cell cycle progression, and may provide new insights into modulating cellular homeostasis and maintaining genomic integrity in the prevention of aging and cancer.
Journal ArticleDOI
Hypoxia-autophagy axis induces VEGFA by peritoneal mesothelial cells to promote gastric cancer peritoneal metastasis through an integrin α5-fibronectin pathway
Xiaoxun Wang,Xiaofang Che,Yang Yu,Yu Cheng,Ming Bai,Zichang Yang,Qiqiang Guo,Xiaochen Xie,Danni Li,Min Guo,Kezuo Hou,Wendong Guo,Xiujuan Qu,Liu Cao +13 more
TL;DR: The findings have elucidated the mechanisms by which PMCs promote PM in GC in hypoxic environments and provides a theoretical basis for considering autophagic pathways or VEGFA as potential therapeutic targets to treat peritoneal metastasis.
Journal ArticleDOI
Autophagy resists EMT process to maintain retinal pigment epithelium homeostasis.
Hao Feng,Xin Zhao,Qiqiang Guo,Yanling Feng,Mengtao Ma,Wendong Guo,Xiang Dong,Chengsi Deng,Chunlu Li,Xiaoyu Song,Shuai Han,Liu Cao +11 more
TL;DR: Observations reveal that autophagy may be an effective way to treat PVR by finding that RPE epithelial properties can be maintained by promoting autophileagy and effectively reversing TFG-β2-induced RPE fibrosis.
Journal ArticleDOI
Atg7 inhibits Warburg effect by suppressing PKM2 phosphorylation resulting reduced epithelial-mesenchymal transition.
Yanling Feng,Jingwei Liu,Wendong Guo,Yi Guan,Hongde Xu,Qiqiang Guo,Xiaoyu Song,Fei Yi,Ting Liu,Wenyu Zhang,Xiang Dong,Longyue L Cao,Brian P. O’Rourke,Liu Cao +13 more
TL;DR: A molecular link between Atg7 and the Warburg effect is revealed, which may provide insight into novel strategies for cancer treatment and help clarify the role of autophagy in tumorigenesis.