H
Hongling Li
Researcher at Peking Union Medical College
Publications - 28
Citations - 1800
Hongling Li is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Mesenchymal stem cell & Adipogenesis. The author has an hindex of 17, co-authored 26 publications receiving 1496 citations. Previous affiliations of Hongling Li include Peking Union Medical College Hospital.
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Journal ArticleDOI
Upregulation of miR-22 promotes osteogenic differentiation and inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells by repressing HDAC6 protein expression.
Shan Huang,Shihua Wang,Chunjing Bian,Zhuo Yang,Hong Zhou,Yang Zeng,Hongling Li,Qin Han,Robert Chunhua Zhao +8 more
TL;DR: The results suggested that miR-22 acted as a critical regulator of balance between adipogenic and osteogenic differentiation of hADMSCs by repressing its target HDAC6.
Journal ArticleDOI
miR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1
TL;DR: The findings suggest that miR-17-5p plays an important role in breast cancer cell invasion and migration by suppressing HBP1 and subsequent activation of Wnt/β-catenin.
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Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NFκB-TLR signaling pathway
Xiaoxia Li,Shihua Wang,Rongjia Zhu,Hongling Li,Qin Han,Robert Chunhua Zhao,Robert Chunhua Zhao +6 more
TL;DR: A novel mechanism by which lung tumor cell-derived exosomes induce pro-inflammatory activity of MSCs which in turn get tumor supportive characteristics is suggested.
Journal ArticleDOI
MicroRNA-100 regulates osteogenic differentiation of human adipose-derived mesenchymal stem cells by targeting BMPR2
Yang Zeng,Xuebin Qu,Hongling Li,Shan Huang,Shihua Wang,Qilin Xu,Ruizhu Lin,Qin Han,Jing Li,Robert Chunhua Zhao +9 more
TL;DR: Findings imply that miR‐100 plays a negative role in osteogenic differentiation and might act through targeting BMPR2, similar to the effect of upregulation miR-100.
Journal ArticleDOI
miR-17-5p and miR-106a are involved in the balance between osteogenic and adipogenic differentiation of adipose-derived mesenchymal stem cells
Hongling Li,Tangping Li,Shihua Wang,Jianfeng Wei,Junfen Fan,Jing Li,Qin Han,Lianming Liao,Changshun Shao,Robert Chunhua Zhao,Robert Chunhua Zhao +10 more
TL;DR: MiR-17-5p and miR-106a regulate osteogenic and adipogenic lineage commitment of hADSCs by directly targeting BMP2, and subsequently decreased osteogenic TAZ, MSX2 and Runx 2, and increased adipogenic C/EBPα and PPARγ.