Showing papers in "Stem Cell Research in 2013"

TL;DR: This study shows that intact exosomes restore bioenergetics, reduce oxidative stress and activate pro-survival signaling, thereby enhancing cardiac function and geometry after myocardial I/R injury, and Hence, mesenchymal stem cell-derived exosome are a potential adjuvant to reperfusion therapy for my cardiac infarction.

TL;DR: It is concluded that the short G1 phase observed in murine ESCs was a determinant of naïve pluripotency and was partially under the control of LIF signaling.

TL;DR: A surface marker, the nerve growth factor receptor, is found in Nestin-GFP+/NG2-DsRed+/Tuj1+ cells and can be used to identify and isolate them from mixed cell populations in nontransgenic species for clinical purposes.

TL;DR: The current state of knowledge regarding mechanisms behind the therapeutic effects of MSCs in the treatment of experimental liver diseases is visited, questions about efficacy and risk are addressed, and recent clinical advances involving MSC-based therapies are discussed.

TL;DR: Induced pluripotent stem cells (iPSCs) generated from dermal fibroblasts of three patients with different mutations in TAZ1 expressed pluripotency markers are demonstrated to be capable of modeling BTHS by recapitulating the disease phenotype and thus are important tools for studying the disease mechanism.

TL;DR: ASCs are an interesting source of stem cells for efficiently reducing hypertrophy and dedifferentiation of chondrocytes, at least partly via the secretion of HGF, which supports the interest of using these cells in therapies for osteo-articular diseases.

TL;DR: MiR-17-5p and miR-106a regulate osteogenic and adipogenic lineage commitment of hADSCs by directly targeting BMP2, and subsequently decreased osteogenic TAZ, MSX2 and Runx 2, and increased adipogenic C/EBPα and PPARγ.

TL;DR: This system is the first to enable an efficient scale-up bioprocess in completely xeno-free condition for the expansion and cryopreservation of hiPSCs with the quantity and quality compliant for clinical applications.

TL;DR: It is demonstrated that laminin, a commonly used substrate for iPSC cultures, was inefficient to promote fully functional maturation of hiPSC-derived neurons, and astrocytes played a critical role in promoting neural differentiation and functional m maturity of human neurons derived from hiPSCs.

TL;DR: It is reported that aspiration lesion in the motor cortex induces a transient, but significant increase in the proliferation as well as neurogenesis in the SVZ, and the potential of the endogenous neural progenitors in cortical repair is indicated.

TL;DR: A simple method to generate and expand multipotent, self-renewing pre-rosette neural stem cells from both human embryonic stem cells and human induced pluripotent stem cells without utilizing embryoid body formation, manual selection techniques, or complex combinations of small molecules is developed.

TL;DR: The induction of teratoma in mice by the transplantation of stem cells into extra-uterine sites has been used as a read-out for cellular pluripotency since the initial description of this phenomenon in 1954, but the scientific significance of this assay has been debated.

TL;DR: It is demonstrated that transplanted hemopoietic stem cells (HSC) preferentially lodge within two cells of mature megakaryocytes (MM) and that IGF-1/IGFBP-3 induced increased hemopositive cell proliferation can be blocked by an anti-IGF-1 neutralising antibody.

TL;DR: This study observed in neurons differentiated from both hiPS cell lines that Aβ induced toxicity correlated with cell cycle re-entry and was inhibited by pharmacological inhibitors or shRNAs against Cyclin-dependent kinase 2 (Cdk2).

TL;DR: A gene list is generated which defines pluripotency and establishes a baseline for the pluripotent state and lists of genes enriched under both differentiation conditions which show the proposed bias toward independent cell fates are provided.

TL;DR: An iPSC-CM marking system using recombinant adenoviral reporter constructs with atrial- or ventricular-specific myosin light chain-2 (MLC-2) promoters to purify a highly homogeneous population of i PSC-CMs is developed.

TL;DR: In this article, the authors observed the onset of population heterogeneity by conducting long-term continuous in vitro observation of human adult bone marrow stromal cell populations, a subset of which has been shown to be stem cells (also known as bone marrow-derived MSCs).

TL;DR: It is demonstrated that ASC transplantation is effective in treating acetaminophen liver injury by enhancing hepatocyte regeneration and inhibiting liver stress and inflammatory signaling.

TL;DR: Stemformatics provides a simple mechanism to create, share and analyse gene sets, providing a repository of community-annotated stem cell gene lists that are informative about pathways, lineage commitment, and common technical artefacts.

TL;DR: These studies suggest that TGF-β signaling in stromal cells acts upstream of FGF-10 to regulate epithelial stem cell growth in the adult lung.

TL;DR: It is demonstrated that quiescent NSCs are specifically enriched in the LeX(bright)/EGFR-negative population, and the GABAAR signaling is identified as a regulator of the SVZ niche size by modulating the quiescence of N SCs.

TL;DR: It is identified that resveratrol significantly reduced the self-renewal and tumor-initiating capacity of patient-derived G SCs and targeting GSCs via the p53-Nanog axis, with resver atrol for instance, could be a therapeutic strategy against glioblastoma.

TL;DR: These findings have important clinical implications and indicate that enhanced sensitization to repolarization-prolonging compounds through pharmacotherapy or genetic predisposition should be taken into account when assessing drug safety.

TL;DR: It is demonstrated that the Bcl-2 adenovirus E1B 19kDa-interacting protein 3 (BNIP3), which is regulated by HIF-1 and activates cell death, isregulated by miR-210 in NPCs under hypoxia, and a novel feedback loop of BNIP3 regulation in NPC under hyp oxia is reported.

TL;DR: The onset of senescence-associated molecular changes was variable among subjects and preceded changes in other indicators of BMSC quality and senescences, and a computational biology approach was used to identify a set of genes whose expression at each passage would predict elapsed age of B MSCs.

TL;DR: In this paper, a porcine spermatogonial germ cell (pSGC) line was established and cultured for long periods under a low temperature culture environment in vitro, and pSGCs could stably maintain undifferentiated germ cell and stem cell characteristics for over 60 days during culture at 31°C.

TL;DR: The results establish first-timely that hBMSCs' behavior can be modified and optimized in response to defined mechanical stimulation and suggest that mechanical stress preconditions hB MSCs for improved therapeutic performance without genetic manipulations and that mechanically preconditioned h BMSCs will be advantageous for hBBSC-based tissue regeneration.

TL;DR: The data indicate that hUCSCs are capable of promoting the M2 polarization of macrophages at injury sites, suggesting a new mechanism for h UCSC-mediated protection in renal IRI.

TL;DR: Evidence suggesting that EDA sustains Wnt/β-catenin signaling activity via activating integrin/FAK/ERK pathway is provided, and EDA is essential for the maintenance of the properties of CD133(+)/CD44(+) colon cancer cells.

TL;DR: The present study evaluated the direct effects of HMGA2 on the cellular aging and proliferation of hUCBSCs and investigated potential regulatory mechanisms responsible for the corresponding functions and found that the overexpression ofHMGA2 enhanced proliferation and reduced or even reversed the in vitro aging process of h UCBSCs.