Hongyu Lin

TL;DR: In this article, the effects of manganese doping on changes of ferrite crystal structures, magnetic properties, and contrast abilities were investigated, and a successful one-pot synthesis of uniform manganized-doped magnetite (MnxFe3-xO4) nanoparticles with different manganous contents (x = 0.06).

TL;DR: In vitro and in vivo experiments reveal the excellent anticancer efficacy of activatable mitochondria-targeting organoarsenic prodrugs, underscoring the encouraging outlook of this strategy for effective cancer therapy.

TL;DR: This protocol describes targetable reactive electrophiles and oxidants (T-REX)—a live-cell-based tool designed to interrogate the consequences of specific and time-resolved redox events, and screen for bona fide redox-sensor targets.

TL;DR: The T-REX platform presents a previously unavailable opportunity to elucidate the functional consequences of small-molecule-signal- and protein-target-specific electrophilic modifications in an otherwise unaffected cellular background.

TL;DR: A modest level of HNEylation on a single target is sufficient to elicit the pharmaceutically important antioxidant response element (ARE) activation, and the resultant strength of ARE induction recapitulates that observed from whole-cell electrophilic perturbation, providing the first evidence that single-target LDE modifications are important individual events in mammalian physiology.