Hovik Farghaian

TL;DR: It is proposed ATP13A2's modulation of zinc levels in MVBs can regulate the biogenesis of exosomes capable of containing α-Synuclein, the first PD-associated gene involved in exosome biogenesis and indicates a potential neuroprotective role ofExosomes in PD.

TL;DR: Because its expression is highest in relatively plastic regions of the adult brain (cortex, hippocampus), scapinin is a new regulator of neurite outgrowth and neuroplasticity in the brain.

TL;DR: The lipid kinase phosphatidylinositol 4-kinase II α (PI4KIIα) is a novel substrate of GSK3 that regulates trafficking and cell-surface expression of neurotransmitter receptors in neurons, and a reduction in PI4Kiiα expression or phosphorylation increases α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression at the surface of hippocampal neurons.

TL;DR: Bioinformatics and biochemical validation used to identify novel brain substrates of the Ser/Thr kinase glycogen synthase kinase 3 (GSK3) identified the brain-enriched cytoskeleton-associated protein β-adducin as a likely substrate of GSK3.

TL;DR: In this article , the authors evaluated the impact of a pilot multi-disciplinary heart failure clinic (MDT-HFc) at an institution on HF-related outcomes, including rehospitalisation.