Ann M. Turnley

TL;DR: It is demonstrated that adult mice lacking EphA4 (-/-), a molecule essential for correct guidance of spinal cord axons during development, exhibit axonal regeneration and functional recovery after spinal cord hemisection.

TL;DR: In this article, a zebrafish model of ALS and identified Epha4, a receptor in the ephrin axonal repellent system, as a modifier of the disease phenotype in fish, rodents and humans.

TL;DR: Preference nuclear localization of the α2, β1, and γ1 subunits suggests new functions of the AMP‐activated protein kinase, and the different expression patterns and cellular localization between the two catalytic subunits α1 and α2 point to different physiological roles.

TL;DR: This study shows that the neurotrophic cytokine leukemia inhibitory factor (LIF) directly prevents oligodendrocyte death in animal models of MS and demonstrates that this therapeutic effect complements endogenous LIF receptor signaling, which already serves to limit oligodendedrocytes loss during immune attack.

TL;DR: It is shown that neural precursors isolated from the developing forebrain of mice that are deficient in the gene for the low-affinity leukemia inhibitory factor receptor (LIFR-/-) fail to generate astrocytes expressing glial fibrillary acidic protein (GFAP) when cultured in vitro, and indeed the LIF-deficient animals show a significant reduction in the number of GFAP cells in the hippocampus.