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William E. Hughes
Researcher at University of New South Wales
Publications - 64
Citations - 3819
William E. Hughes is an academic researcher from University of New South Wales. The author has contributed to research in topics: Phosphorylation & Protein kinase C. The author has an hindex of 30, co-authored 59 publications receiving 3275 citations. Previous affiliations of William E. Hughes include Children's Medical Research Institute & Garvan Institute of Medical Research.
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Journal ArticleDOI
I-motif DNA structures are formed in the nuclei of human cells
Mahdi Zeraati,Mahdi Zeraati,David B. Langley,Peter R. Schofield,Aaron L. Moye,Romain Rouet,William E. Hughes,William E. Hughes,Tracy M. Bryan,Marcel E. Dinger,Marcel E. Dinger,Daniel Christ,Daniel Christ +12 more
TL;DR: The generation and characterization of an antibody fragment (iMab) is reported that recognizes i-motif structures with high selectivity and affinity, enabling the detection of i- Motifs in the nuclei of human cells and providing evidence that i-Motif structures are formed in regulatory regions of the human genome, including promoters and telomeric regions.
Journal ArticleDOI
Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise
Martin Whitham,Martin Whitham,Benjamin L. Parker,Martin Friedrichsen,Janne R. Hingst,Marit Hjorth,Marit Hjorth,William E. Hughes,William E. Hughes,Casey L. Egan,Lena Cron,Kevin I. Watt,Rhiannon P. Kuchel,Navind Jayasooriah,Navind Jayasooriah,Emma Estevez,Tim Petzold,Catherine M. Suter,Paul Gregorevic,Bente Kiens,Erik A. Richter,David E. James,Jørgen F. P. Wojtaszewski,Mark A. Febbraio,Mark A. Febbraio +24 more
TL;DR: A new paradigm by which tissue crosstalk during exercise can exert systemic biological effects is identified, identified by employing arteriovenous balance studies across the contracting human limb to identify several novel candidate myokines released into circulation independently of classical secretion.
Journal ArticleDOI
Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility.
Tony Ng,Tony Ng,Maddy Parsons,William E. Hughes,James Monypenny,Daniel Zicha,Alexis Gautreau,Monique Arpin,Steve Gschmeissner,Peter J. Verveer,Philippe I. H. Bastiaens,Peter J. Parker +11 more
TL;DR: It is provided the first evidence that PKCα or a PKC α‐associated serine/threonine kinase can phosphorylate the ERM C‐terminal threonine residue within a kinase–ezrin molecular complex in vivo.
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A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton.
Danielle K. Lynch,Stephanie C. Winata,Ruth J. Lyons,William E. Hughes,Gillian M. Lehrbach,Valerie C. Wasinger,Garry L. Corthals,Stuart J. Cordwell,Roger J. Daly +8 more
TL;DR: By binding both CD2AP and the Arp2/3 complex, cortactin links receptor endocytosis to actin polymerization, which may facilitate the trafficking of internalized growth factor receptors.
Journal ArticleDOI
Increased Fatty Acid Desaturation and Enhanced Expression of Stearoyl Coenzyme A Desaturase Protects Pancreatic β-Cells from Lipoapoptosis
Anna K. Busch,Ebru Gurisik,Ebru Gurisik,Ebru Gurisik,Damien Cordery,Michelle Sudlow,Gareth Denyer,D. Ross Laybutt,William E. Hughes,Trevor J. Biden,Trevor J. Biden +10 more
TL;DR: The results suggest that desaturation per se is more important in protecting beta-cells from the cytotoxic effects of palmitate than is the nature of neutral lipid storage pool thus generated.