H
Howard Bregman
Researcher at Agios Pharmaceuticals
Publications - 1
Citations - 379
Howard Bregman is an academic researcher from Agios Pharmaceuticals. The author has an hindex of 1, co-authored 1 publications receiving 244 citations.
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Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis
Monika Bambouskova,Laurent Gorvel,Vicky Lampropoulou,Alexey Sergushichev,Ekaterina Loginicheva,Kendall Johnson,Daniel Korenfeld,Mary Elizabeth Mathyer,Hyeryun Kim,Li-Hao Huang,Dustin Duncan,Howard Bregman,Abdurrahman Keskin,Andrea Santeford,Rajendra S. Apte,Raghav Sehgal,Britney Johnson,Gaya K. Amarasinghe,Miguel P. Soares,Takashi Satoh,Shizuo Akira,Tsonwin Hai,Cristina de Guzman Strong,Karine Auclair,Thomas P. Roddy,Scott A. Biller,Marko Jovanovic,Eynav Klechevsky,Kelly M. Stewart,Gwendalyn J. Randolph,Maxim N. Artyomov +30 more
TL;DR: The immunoregulatory metabolite itaconate and its dimethyl derivative induce electrophilic stress and react with glutathione to induce both Nrf2-dependent and NRF2-independent responses, resulting in AF3-mediated inhibition of the inflammation-related protein IκBζ.