M
Miguel P. Soares
Researcher at Instituto Gulbenkian de Ciência
Publications - 165
Citations - 20857
Miguel P. Soares is an academic researcher from Instituto Gulbenkian de Ciência. The author has contributed to research in topics: Heme oxygenase & Heme. The author has an hindex of 68, co-authored 159 publications receiving 18720 citations. Previous affiliations of Miguel P. Soares include Beth Israel Deaconess Medical Center & Utrecht University.
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Journal ArticleDOI
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
Leo E. Otterbein,Leo E. Otterbein,Fritz H. Bach,Jawed Alam,Miguel P. Soares,Hong-Tao Lu,Mark Allen Wysk,Roger J. Davis,Richard A. Flavell,Augustine M.K. Choi,Augustine M.K. Choi +10 more
TL;DR: It is demonstrated here that carbon monoxide, a by-product of heme catabolism by heme oxygenase, mediates potent anti-inflammatory effects and may have an important protective function in inflammatory disease states and thus has potential therapeutic uses.
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Disease Tolerance as a Defense Strategy
TL;DR: The notion of disease tolerance has been introduced into the conceptual tool kit of immunology as discussed by the authors, which will expand our understanding of infectious diseases and host pathogen interactions. But, it has not yet been applied to human studies.
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Heme oxygenase-1: unleashing the protective properties of heme
TL;DR: It is suggested that the products of HO-1 action could be valuable therapeutic agents and speculate thatHO-1 functions as a "therapeutic funnel", mediating the beneficial effects attributed to other molecules, such as interleukin-10 (IL-10), inducible nitric oxide synthase (NOS2; iNOS) and prostaglandins.
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Mechanisms of Cell Protection by Heme Oxygenase-1
TL;DR: The mechanism underlying this cytoprotective effect relies on the ability of HO-1 to catabolize free heme and prevent it from sensitizing cells to undergo programmed cell death.
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Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis.
Sophie Brouard,Leo E. Otterbein,Josef Anrather,Edda Tobiasch,Fritz H. Bach,Augustine M.K. Choi,Miguel P. Soares +6 more
TL;DR: The data demonstrate that the antiapoptotic effect of HO-1 in ECs is mediated by CO and more specifically via the activation of p38 MAPK by CO.