Structure-activity relationship of antibacterial chalcones.

Chalcones are absorbed in the daily diet and appear to be promising cancer chemopreventive agents. Chalcones represent an important group of the polyphenolic family, which includes a large number of naturally occurring molecules. This family possesses an interesting spectrum of biological activities, including antioxidative, antibacterial, anti-inflammatory, anticancer, cytotoxic, and immunosuppressive potential. Compounds of this family have been shown to interfere with each step of carcinogenesis, including initiation, promotion and progression. Moreover, numerous compounds from the family of dietary chalcones appear to show activity against cancer cells, suggesting that these molecules or their derivatives may be considered as potential anticancer drugs. This review will focus primarily on prominent members of the chalcone family with an 1,3-diphenyl-2-propenon core structure. Specifically, the inhibitory effects of these compounds on the different steps of carcinogenesis that reveal interesting chemopreventive and chemotherapeutic potential will be discussed.

/pdf/dietary-chalcones-with-chemopreventive-and-chemotherapeutic-xk05uheiq2.pdf

Dietary chalcones with chemopreventive and chemotherapeutic potential

Synthesis of novel pyrazolic analogues of chalcones and their 3-aryl-4-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-1-phenyl-1H-pyrazole derivatives as potential antitumor agents

Quinoline-based antimalarial hybrid compounds.

http://ir.lib.cyut.edu.tw:8080/bitstream/310901800/11195/3/51.pdf

Differential effects of synthesized 2′-oxygenated chalcone derivatives: modulation of human cell cycle phase distribution

Synthesis, characterization and in vitro anti-invasive activity screening of polyphenolic and heterocyclic compounds

Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part II

/pdf/synthetic-and-mass-spectral-fragmentation-studies-on-4yr3op0bf8.pdf

Synthetic and mass spectral fragmentation studies on trisubstituted 2h-pyran-2-ones and comparative eims behaviour of biologically active 3,5-disubsti tuted pyrazoles and isoxazoles

Hriday N Jha

Papers

Synthesis, characterization and in vitro anti-invasive activity screening of polyphenolic and heterocyclic compounds

Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part II

Synthetic and mass spectral fragmentation studies on trisubstituted 2h-pyran-2-ones and comparative eims behaviour of biologically active 3,5-disubsti tuted pyrazoles and isoxazoles