Open AccessJournal Article
Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part II
Hanumanthrao Guru Raj,V. S. Parmar,S. C. Jain,Sanjay Goel,Amit Singh,K.C. Gupta,Vishwajeet Rohil,Yogesh K Tyagi,Hriday N Jha,Carl Erik Olsen,Jesper Wengel +10 more
TLDR
Parenteral administration of DAMC to rats caused significant inhibition of AFB1 binding to hepatic DNA in vivo as well as AFB1-induced micronuclei formation in bone marrow cells, highlighting the antimutagenic potential of DamC.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 1998-01-01 and is currently open access. It has received 47 citations till now. The article focuses on the topics: Mechanism (sociology).read more
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Synthesis of novel amino and acetyl amino-4-methylcoumarins and evaluation of their antioxidant activity
Yogesh K Tyagi,Ajit Kumar,Hanumantharao G. Raj,Parag Vohra,Garima Gupta,Ranju Kumari,Pankaj Kumar,Rajinder K. Gupta +7 more
TL;DR: It is demonstrated that amino group is an effective substitute for the hydroxyl group for antioxidant property and produced a dramatic inhibition of lipid peroxidation.
Journal ArticleDOI
Mechanism of biochemical action of substituted 4-methylcoumarins. Part 11: Comparison of the specificities of acetoxy derivatives of 4-methylcoumarin and 4-phenylcoumarin to acetoxycoumarins: protein transacetylase.
Ajit Kumar,Brajendra K. Singh,Rahul Tyagi,Rahul Tyagi,Sapan K. Jain,Sunil K. Sharma,Sunil K. Sharma,Ashok K. Prasad,Hanumantharao G. Raj,Ramesh C. Rastogi,Arthur C. Watterson,Virinder S. Parmar,Virinder S. Parmar +12 more
TL;DR: It is demonstrated that the acetoxy coumarins and acetoxy dihydrocoumarins having a methyl group instead of a phenyl ring at the C-4, when used as the substrates, resulted in enhancement of TAase activity, while the saturation of double bond at C-3 and C- 4 position had no effect on TA enzyme activity.
Journal ArticleDOI
7,8-Dihydroxy-4-methylcoumarin induces apoptosis of human lung adenocarcinoma cells by ROS-independent mitochondrial pathway through partial inhibition of ERK/MAPK signaling
TL;DR: It is shown that, in A549 human NSCLC cells, DHMC induces apoptosis through mitochondria‐mediated caspase‐dependent pathway and results in the present study for the first time suggest that DHMC induce apoptosis in human lung A549 cells through partial inhibition of ERK/MAPK signaling.
Journal ArticleDOI
Antioxidant activity of 4-methylcoumarins
Jens Z. Pedersen,Cristina Oliveira,Sandra Incerpi,Vineet Kumar,Vineet Kumar,Anna Maria Fiore,Paolo De Vito,Ashok K. Prasad,Sanjay V. Malhotra,Virinder S. Parmar,Luciano Saso +10 more
TL;DR: The radical scavenging capacity of 22 structurally related natural and synthetic 4‐methylcoumarins is determined, by measuring their reaction with radicals, galvinoxyl and 2,2‐diphenyl‐1‐picrylhydrazyl, using electron paramagnetic resonance spectroscopy.
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Apoptogenic effect of 7,8-diacetoxy-4-methylcoumarin and 7,8-diacetoxy-4-methylthiocoumarin in human lung adenocarcinoma cell line: role of NF-κB, Akt, ROS and MAP kinase pathway
TL;DR: Results of present study suggest that downregulation of Bcl-xl, Cox-2 and mitogen activated protein kinase pathway and upregulation of p53, Akt and NF-kappaB pathway are involved in the underlying molecular mechanism of apoptosis induction by DAMC and DAMTC in A549 cells.
References
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A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid
TL;DR: The present study arose from the observation that a more intense colour was sometimes produced if, instead of being heated at 1000 for 10 min., the reaction mixture was allowed to stand overnight at room temperature.
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Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat.
Ronald A. Lubet,Richard T. Mayer,John W. Cameron,Raymond W. Nims,M. Danny Burke,Thomas Wolff,F. Peter Guengerich +6 more
TL;DR: The O-dealkylation of pentoxyresorufin by rat liver microsomes was examined and it was observed that this activity, in microsome for Aroclor-pretreated rats, was dependent on O2 and was inhibited by metyrapone and SKF 525-A, indicative of cytochrome P-450 mediation in the reaction.
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Aflatoxin B1-2,3-oxide: evidence for its formation in rat liver in vivo and by human liver microsomes in vitro.
TL;DR: The data indicate that approximately 60% of the nucleic acid adducts were derived from reactions in vivo with aflatoxin B1-2,3-oxide, which is a probable ultimate carcinogenic metabolite.
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Metabolic activation of aflatoxin B1: patterns of DNA adduct formation, removal, and excretion in relation to carcinogenesis.
TL;DR: In this paper, the authors studied the patterns of DNA adduct formation, removal, and excretion in relation to carcinogenesis drug metabolism and showed that these patterns are related to drug metabolism.