H
Hsin Chen
Researcher at University of California, San Francisco
Publications - 8
Citations - 399
Hsin Chen is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Actin-binding protein & Antigen. The author has an hindex of 7, co-authored 8 publications receiving 316 citations. Previous affiliations of Hsin Chen include Duke University.
Papers
More filters
Journal ArticleDOI
Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses.
Tangsheng Yi,Jianhua Li,Hsin Chen,Jiaxi Wu,Jinping An,Ying Xu,Yongmei Hu,Clifford A. Lowell,Jason G. Cyster +8 more
TL;DR: Findings provide an explanation for the adjuvant mechanism of SRBCs and reveal that splenic DCs survey blood cells for missing self-CD47, a process that might contribute to detecting and mounting immune responses against pathogen-infected RBCs.
Journal ArticleDOI
Inhibitory GEF Phosphorylation Provides Negative Feedback in the Yeast Polarity Circuit
TL;DR: In the budding yeast Saccharomyces cerevisiae, the catalytic activity of the Cdc42-directed GEF is inhibited by CDC42-stimulated effector kinases, thus providing negative feedback, and replacing the GEF with a phosphosite mutant GEF abolishes oscillations and leads to the accumulation of excess GTP-Cdc42 and other polarity factors at the front.
Journal ArticleDOI
Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node
Yang Zhang,Theodore L. Roth,Elizabeth E. Gray,Hsin Chen,Lauren B. Rodda,Yin Liang,Patrick Ventura,Saul A. Villeda,Paul R. Crocker,Jason G. Cyster +9 more
TL;DR: It is reported that IL7RhiCcr6+ lymphocytes in mouse LNs rapidly produce IL17 upon bacterial and fungal challenge, and it is shown that these innate-like lymphocytes are mostly LN resident and Ccr6 is required for their accumulation near the SCS and for efficient IL17 induction.
Journal ArticleDOI
GPR55 regulates intraepithelial lymphocyte migration dynamics and susceptibility to intestinal damage
TL;DR: It is demonstrated that GPR55, a receptor that mediates migration inhibition in response to lysophosphatidylinositol (LPI), negatively regulates T cell receptor γδ (TCRγδ) IEL accumulation in the small intestine.
Journal ArticleDOI
Cdc42p regulation of the yeast formin Bni1p mediated by the effector Gic2p.
TL;DR: The CDC42p effector Gic2p can bind both Bni1p and GTP-Cdc42p, providing a novel regulatory input.