Jinping An

TL;DR: Treatment with the IFN-α/β inducer polyinosine polycytidylic acid inhibited egress by a mechanism that was partly lymphocyte-intrinsic, and observations indicate that CD69 forms a complex with and negatively regulates S1P1 and that it functions downstream ofIFN- α/β, and possibly other activating stimuli, to promote lymphocyte retention in lymphoid organs.

TL;DR: Selective ablation of follicular dendritic cells in mice results in disorganization of primary follicles and dispersal of B cells out of splenic germinal centers.

TL;DR: It is shown that GCB-DLBCL-associated mutations occurring in S1PR2 frequently disrupt the receptor’s Akt and migration inhibitory functions, and a Gα13-dependent pathway that exerts dual actions in suppressing growth and blocking dissemination of germinal centre B cells is identified.

TL;DR: It is shown that CXCR4-deficient GC B cells, which are restricted to the LZ, are gradually outcompeted by WT cells indicating an essential role for DZ access, and a network of DZ CXCL12-expressing reticular cells that likely support DZ functions are identified.

TL;DR: A function for coronin 1A in T cell egress is established, a surface of coronin involved in Arp2/3 regulation is identified and actin regulation is a biological process defective in human and mouse severe combined immunodeficiency.