Saul A. Villeda

TL;DR: Heterochronic parabiosis shows that blood-borne factors present in the systemic milieu can inhibit or promote adult neurogenesis in an age-dependent fashion in mice, and identifies chemokines—including CCL11 (also known as eotaxin)—the plasma levels of which correlate with reduced neuroGenesis in heterochronics parabionts and aged mice and which are increased in the plasma and cerebrospinal fluid of healthy ageing humans.

TL;DR: Exposure of aged mice to young blood late in life is capable of rejuvenating synaptic plasticity and improving cognitive function, and structural and cognitive enhancements elicited by exposure are mediated by activation of the cyclic AMP response element binding protein (Creb) in the aged hippocampus.

TL;DR: FoxO3, a member of a transcription factor family known to extend lifespan in invertebrates, regulates the NSC pool and the ability of FoxO3 to prevent the premature depletion of NSCs might have important implications for counteracting brain aging in long-lived species.

TL;DR: In this paper, the authors identify β2-microglobulin (B2M), a component of major histocompatibility complex class 1 (MHC I) molecules, as a circulating factor that negatively regulates cognitive and regenerative function in the adult hippocampus.

TL;DR: Colony-stimulating factor 1 and IL-34 protect against and partially reverse neurodegeneration in mice in part via promoting CREB signaling.