Lauren B. Rodda

TL;DR: Using droplet-based single-cell RNA sequencing, Wang et al. as discussed by the authors identified nine peripheral LN non-endothelial stromal cells (SCs) clusters, including Ccl19hi T-zone reticular cells (TRCs), marginal RETicular cells, follicular dendritic cells (FDCs), and perivascular cells.

TL;DR: The hypothesis that CCR6 expression in PP B cells is necessary for their efficient switching to IgA and for production of intestinal IgA against cholera toxin and commensal bacteria is pursued.

TL;DR: These findings establish CRCs as a major stromal cell type in the GC DZ and suggest that CRCs support critical activities of GC B cells in the DZ niche through Cxcl12 expression and direct cell–cell interactions.

TL;DR: Investigating how vaccine-induced memory is shaped by previous infection found that following vaccination, previously infected individuals generated more SARS-CoV-2 RBD-specific memory B cells and variant-neutralizing antibodies and a distinct population of IFN-γ and IL-10-expressing memory Sars-Cov-2 spike-specific CD4+ T cells than previously naive individuals.

TL;DR: It is reported that IL7RhiCcr6+ lymphocytes in mouse LNs rapidly produce IL17 upon bacterial and fungal challenge, and it is shown that these innate-like lymphocytes are mostly LN resident and Ccr6 is required for their accumulation near the SCS and for efficient IL17 induction.