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Hua Lin Wu

Researcher at National Cheng Kung University

Publications -  193
Citations -  5624

Hua Lin Wu is an academic researcher from National Cheng Kung University. The author has contributed to research in topics: Thrombomodulin & Angiogenesis. The author has an hindex of 41, co-authored 186 publications receiving 5167 citations. Previous affiliations of Hua Lin Wu include National Taiwan University.

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Detection of HCV RNA in saliva, urine, seminal fluid, and ascites

TL;DR: The presence ofHCV RNA in saliva and seminal fluid of patients positive for serum HCV RNA suggests sexual and household contact as likely modes of nonparenteral transmission of type C hepatitis.
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Suppression of angiogenesis and tumor growth by the inhibitor K1–5 generated by plasmin-mediated proteolysis

TL;DR: It is demonstrated that urokinase-activated plAsmin can process plasminogen to release an angiogenesis inhibitor, K1-5 (protease- activated kringles 1-5), and this findings suggest that the plasmine-mediated proteolysis may be involved in the negative switch ofAngiogenesis.
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Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response.

TL;DR: It is demonstrated that recombinant N-terminal lectinlike domain of TM (rTMD1) functions as a protective agent against sepsis caused by Gram-negative bacterial infections and can be used to defend against bacterial infection and inhibit LPS-induced inflammatory responses, suggesting that rT MD1 may be valuable in the treatment of severe inflammation in sepsi.
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Thrombomodulin-mediated cell adhesion: involvement of its lectin-like domain.

TL;DR: Thrombomodulin can function as a Ca2+-dependent cell-to-cell adhesion molecule and binding of specific carbohydrates to the lectin-like domain is essential for this specific function.