K
Kung Chia Young
Researcher at National Cheng Kung University
Publications - 81
Citations - 2488
Kung Chia Young is an academic researcher from National Cheng Kung University. The author has contributed to research in topics: Hepatitis C virus & Hepatitis B virus. The author has an hindex of 27, co-authored 81 publications receiving 2269 citations. Previous affiliations of Kung Chia Young include National Chung Cheng University & University of Southern California.
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Journal ArticleDOI
Detection of HCV RNA in saliva, urine, seminal fluid, and ascites
TL;DR: The presence ofHCV RNA in saliva and seminal fluid of patients positive for serum HCV RNA suggests sexual and household contact as likely modes of nonparenteral transmission of type C hepatitis.
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Identification of a ribavirin-resistant NS5B mutation of hepatitis C virus during ribavirin monotherapy.
Kung Chia Young,Karen L. Lindsay,Ki-Jeong Lee,Wen-Chun Liu,Jian Wen He,Susan L. Milstein,Michael M. C. Lai +6 more
TL;DR: RBV could work as a weak mutagen for HCV RNA in HCV‐infected patients and the selection of an RBV‐resistant variant with a single amino acid substitution in NS5B suggested that RBV may directly interact withHCV RNA polymerase, thus interfering with its enzymatic activity.
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Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells.
Jin-Ching Lee,Chin Kai Tseng,Kung Chia Young,Hung Yu Sun,Shainn Wei Wang,Wei-Chun Chen,Chun-Kuang Lin,Yu Hsuan Wu +7 more
TL;DR: This study aimed to evaluate the anti‐hepatitis C virus activity of andrographolide, a diterpenoid lactone extracted from Andrographis paniculata, and to identify the signalling pathway involved in its antiviral action.
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Mutagenic and inhibitory effects of ribavirin on hepatitis C virus RNA polymerase.
TL;DR: The findings suggest that ribavirin not only is mutagenic but also interferes with HCV polymerase-mediated RNA synthesis, as evidenced by the ability of the polymerase to extend its RNA product many nucleotides beyond the site of RMP incorporation.
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A rapid micro-polymerase chain reaction system for hepatitis C virus amplification
TL;DR: In this article, a rapid micro-polymerase chain reaction (μ-PCR) system was integrated to amplify the complementary DNA (cDNA) molecules of hepatitis C virus (HCV).