H
Hua Long
Researcher at Chongqing University
Publications - 4
Citations - 153
Hua Long is an academic researcher from Chongqing University. The author has contributed to research in topics: Ubiquitin ligase & Carcinogenesis. The author has an hindex of 4, co-authored 4 publications receiving 68 citations.
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Journal ArticleDOI
Reversible regulation of SATB1 ubiquitination by USP47 and SMURF2 mediates colon cancer cell proliferation and tumor progression.
Le Yu,Ling Dong,Yang Wang,Liu Liu,Hua Long,Hui Li,Jinping Li,Xiaolong Yang,Zhaojian Liu,Guangjie Duan,Xiaotian Dai,Zhenghong Lin +11 more
TL;DR: USP47 deficiency impairs transcriptional activity of SATB1 target genes and inhibits colon cancer cell proliferation, migration, and tumorigenesis in a mouse model of colon cancer, and USP47 depletion sensitizes colon cancer cells to 5-FU treatment-induced apoptosis.
Journal ArticleDOI
USP27-mediated Cyclin E stabilization drives cell cycle progression and hepatocellular tumorigenesis.
TL;DR: It is found that ubiquitin-specific peptidase 27 (USP27) promoted Cyclin E stability by negatively regulating its ubiquitination, and suppression of USP27 expression resulted in the inhibition of the growth, migration and invasion of hepatocellular carcinoma.
Journal ArticleDOI
E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation.
TL;DR: A mechanism of lung tumorigenesis that involves HRD1-mediated downregulation of SIRT2 is proposed and interventions targetingHRD1 activity could be a potential therapeutic strategy to treat patients with lung cancer.
Journal ArticleDOI
HRD1-mediated PTEN degradation promotes cell proliferation and hepatocellular carcinoma progression
Liu Liu,Hua Long,Yan Wu,Hui Li,Ling Dong,Julia Li Zhong,Zhaojian Liu,Xiaolong Yang,Xiaotian Dai,Lei Shi,Maozhi Ren,Zhenghong Lin +11 more
TL;DR: The E3 ubiquitin ligase HRD1, which was previously reported to be involved in endoplasmic reticulum associated degradation (ERAD), is identified as one of the PTEN-interacting proteins and proposed as a novel molecular mechanism to promote hepatocellular tumorigenesis via PTEN inactivation.