Huarong Wang

TL;DR: It is found that the expression of ERs was controlled by gonadotropins under physiological conditions and the different regulating patterns of follicle-stimulating hormone and LH on ER levels in vivo versus in vitro determined their distinct actions on oocyte maturation.

TL;DR: It is demonstrated that luteinizing hormone (LH) surge-induced histone deacetylase 3 (HDAC3) downregulation in GCs is essential for oocyte maturation, and HDAC3 inhibits mouse oocytes maturation by negatively regulating the expression of EGF-like factor before the LH surge.

TL;DR: This work identifies a new role of lysine‐specific demethylase 1 (LSD1) in controlling the fate of oocytes in perinatal mice through regulating the level of autophagy and demonstrates that LSD1 exerts its role by regulating the transcription of p62 and affectingAutophagy level through its H3K4me2 dem methylase activity.

TL;DR: This study highlights the important role an overactive CNP/NPR2 system caused by hyperandrogenism in preventing oocytes from maturation and ovulation in PCOS mice and provides insight into potential mechanisms responsible for infertility in women with PCOS.

TL;DR: The effects of BNP and CNP supplementation in the pre-maturation culture media (PMC) on porcine developmental competence from COCs in follicles of different sizes were different and improved the developmental competence of porcines oocytes from small antral follicle in vitro.