H
Huawei Chen
Researcher at AstraZeneca
Publications - 1
Citations - 512
Huawei Chen is an academic researcher from AstraZeneca. The author has contributed to research in topics: Janus kinase & Kinase. The author has an hindex of 1, co-authored 1 publications receiving 490 citations.
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The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors
Michael Hedvat,Dennis Huszar,Andreas Herrmann,Joseph M. Gozgit,Anne Schroeder,Adam Sheehy,Ralf Buettner,David Proia,Claudia M. Kowolik,Hong Xin,Brian Armstrong,Geraldine Bebernitz,Shaobu Weng,Lin Wang,Minwei Ye,Kristen McEachern,Huawei Chen,Deborah Morosini,Kirsten Bell,Marat Alimzhanov,Stephanos Ioannidis,Patricia McCoon,Zhu A. Cao,Hua Yu,Richard Jove,Michael Zinda +25 more
TL;DR: The essential role of Stat3 downstream of Jaks is demonstrated by inhibition of tumor growth using short hairpin RNA targeting Stat3, supporting a key role of Jak kinase activity in Stat3-dependent tumorigenesis.