S
Shaobu Weng
Researcher at AstraZeneca
Publications - 2
Citations - 620
Shaobu Weng is an academic researcher from AstraZeneca. The author has contributed to research in topics: Janus kinase & Carcinogenesis. The author has an hindex of 2, co-authored 2 publications receiving 589 citations.
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Journal ArticleDOI
The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors
Michael Hedvat,Dennis Huszar,Andreas Herrmann,Joseph M. Gozgit,Anne Schroeder,Adam Sheehy,Ralf Buettner,David Proia,Claudia M. Kowolik,Hong Xin,Brian Armstrong,Geraldine Bebernitz,Shaobu Weng,Lin Wang,Minwei Ye,Kristen McEachern,Huawei Chen,Deborah Morosini,Kirsten Bell,Marat Alimzhanov,Stephanos Ioannidis,Patricia McCoon,Zhu A. Cao,Hua Yu,Richard Jove,Michael Zinda +25 more
TL;DR: The essential role of Stat3 downstream of Jaks is demonstrated by inhibition of tumor growth using short hairpin RNA targeting Stat3, supporting a key role of Jak kinase activity in Stat3-dependent tumorigenesis.
Journal ArticleDOI
Antiangiogenic and Antimetastatic Activity of JAK Inhibitor AZD1480
Hong Xin,Andreas Herrmann,Karen L. Reckamp,Wang Zhang,Sumanta K. Pal,Michael Hedvat,Chunyan Zhang,Wei Liang,Anna Scuto,Shaobu Weng,Deborah Morosini,Zhu A. Cao,Michael Zinda,Robert A. Figlin,Dennis Huszar,Richard Jove,Hua Yu +16 more
TL;DR: Zhang et al. as mentioned in this paper showed that AZD1480 can effectively inhibit tumor angiogenesis and metastasis mediated by STAT3 in stromal cells as well as tumor cells.