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Brian Armstrong
Researcher at City of Hope National Medical Center
Publications - 30
Citations - 1541
Brian Armstrong is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: Cancer & Gene silencing. The author has an hindex of 16, co-authored 28 publications receiving 1259 citations. Previous affiliations of Brian Armstrong include Beckman Research Institute.
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Journal ArticleDOI
The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors
Michael Hedvat,Dennis Huszar,Andreas Herrmann,Joseph M. Gozgit,Anne Schroeder,Adam Sheehy,Ralf Buettner,David Proia,Claudia M. Kowolik,Hong Xin,Brian Armstrong,Geraldine Bebernitz,Shaobu Weng,Lin Wang,Minwei Ye,Kristen McEachern,Huawei Chen,Deborah Morosini,Kirsten Bell,Marat Alimzhanov,Stephanos Ioannidis,Patricia McCoon,Zhu A. Cao,Hua Yu,Richard Jove,Michael Zinda +25 more
TL;DR: The essential role of Stat3 downstream of Jaks is demonstrated by inhibition of tumor growth using short hairpin RNA targeting Stat3, supporting a key role of Jak kinase activity in Stat3-dependent tumorigenesis.
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Targeting Stat3 in the myeloid compartment drastically improves the in vivo antitumor functions of adoptively transferred T cells.
Andreas Herrmann,Marcin Kortylewski,Maciej Kujawski,Chunyan Zhang,Karen L. Reckamp,Brian Armstrong,Lin Wang,Claudia M. Kowolik,Jiehui Deng,Robert A. Figlin,Hua Yu +10 more
TL;DR: The results suggest the use of CpG-Stat3siRNA, and possibly other Stat3 inhibitors, as a potent adjuvant to improve T-cell therapies.
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Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue
Anying Song,Wenting Dai,Min Jee Jang,Leonard Medrano,Zhuo Li,Hu Zhao,Mengle Shao,Jiayi Tan,Aimin Li,Tinglu Ning,Marcia M. Miller,Brian Armstrong,Janice M. Huss,Yi Zhu,Yong Liu,Viviana Gradinaru,Xiwei Wu,Lei Jiang,Philipp E. Scherer,Qiong A. Wang +19 more
TL;DR: Functional analyses showed that the low thermogenic brown adipocytes have significant lower basal mitochondrial respiration, and they are specialized in fatty acid uptake, and upon changes in environmental temperature, the two brown adipocyte subpopulations underwent dynamic inter-conversions.
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S1PR1 is an effective target to block STAT3 signaling in activated B cell–like diffuse large B-cell lymphoma
Yong Liu,Jiehui Deng,Lin Wang,Heehyoung Lee,Brian Armstrong,Anna Scuto,Claudia M. Kowolik,Lawrence M. Weiss,Stephen J. Forman,Hua Yu +9 more
TL;DR: The results suggest that targeting S1P/S1PR1 using a clinically relevant and available drug or other approaches is potentially an effective new therapeutic modality for treating the activated B cell-like subtype of diffuse large B-cell lymphoma, a subset of lymphoma that is less responsive to current available therapies.
Journal ArticleDOI
Gold Nanoparticle‐Loaded Neural Stem Cells for Photothermal Ablation of Cancer
Kenna Schnarr,Rachael Mooney,Yiming Weng,Donghong Zhao,Elizabeth Garcia,Brian Armstrong,Alexander J. Annala,Seung U. Kim,Karen S. Aboody,Jacob M. Berlin +9 more
TL;DR: Gold nanoparticles have shown great promise as a novel therapeutic technology for the treatment of cancer due to their non-cytotoxic nature, ease of synthesis and functionalization and, most importantly, their tunable plasmonic properties.