G
Gopal Thinakaran
Researcher at University of Chicago
Publications - 145
Citations - 17678
Gopal Thinakaran is an academic researcher from University of Chicago. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 63, co-authored 138 publications receiving 16690 citations. Previous affiliations of Gopal Thinakaran include Johns Hopkins University School of Medicine & University of Illinois at Chicago.
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Journal ArticleDOI
Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo
David R. Borchelt,Gopal Thinakaran,Christopher B. Eckman,Christopher B. Eckman,Michael K. Lee,Frances Davenport,Tamara Ratovitsky,Cristian Mihail Prada,Grace Kim,Sophia Seekins,Debra Yager,Hilda H. Slunt,Rong Wang,Mary Seeger,Allan I. Levey,Sam Gandy,Neal G. Copeland,Nancy A. Jenkins,Donald L. Price,Steven G. Younkin,Steven G. Younkin,Sangram S. Sisodia +21 more
TL;DR: These studies provide compelling support for the view that one mechanism by which these mutant PS1 cause AD is by increasing the extracellular concentration of Abeta peptides terminating at 42(43), species that foster Abeta deposition.
Journal ArticleDOI
Amyloid Precursor Protein Trafficking, Processing, and Function
Gopal Thinakaran,Edward H. Koo +1 more
TL;DR: Molecular characterization of the secretases involved in Aβ production has facilitated cell biological investigations on APP processing and advanced efforts to model AD pathogenesis in animal models.
Journal ArticleDOI
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
Gopal Thinakaran,David R. Borchelt,Michael K. Lee,Hilda H. Slunt,Lia Spitzer,Grace Kim,Tamara Ratovitsky,Frances Davenport,Christer Nordstedt,Mary Seeger,John Hardy,Allan I. Levey,Sam Gandy,Nancy A. Jenkins,Neal G. Copeland,Donald L. Price,Sangram S. Sisodia +16 more
TL;DR: It is concluded that PS1 is subject to endoproteolytic processing in vivo, and in brains of transgenic mice expressing human PS1, approximately 17 kDa and approximately 27 kDa PS1 derivatives accumulate to saturable levels, and at approximately 1:1 stoichiometry, independent of transgene-derived mRNA.
Journal ArticleDOI
Trafficking and Proteolytic Processing of APP
TL;DR: This chapter outlines how the precursor protein maturates and traffics through the secretory pathway to reach the subcellular locations where the individual secretases are preferentially active and illuminate how neuronal activity and mutations which cause familial Alzheimer disease affect amyloid β-peptide generation and therefore disease onset and progression.
Journal ArticleDOI
The role of presenilin cofactors in the gamma-secretase complex.
Nobumasa Takasugi,Taisuke Tomita,Ikuo Hayashi,Makiko Tsuruoka,Manabu Niimura,Yasuko Takahashi,Gopal Thinakaran,Takeshi Iwatsubo +7 more
TL;DR: Drosophila APH-1 (Aph-1) increases the stability of DrosophILA presenilin (Psn) holoprotein in the complex, whereas PEN-2 is required for endoproteolytic processing of presenILin and conferring γ-secretase activity to the complex.