H
Huck-Hui Ng
Researcher at Genome Institute of Singapore
Publications - 144
Citations - 35090
Huck-Hui Ng is an academic researcher from Genome Institute of Singapore. The author has contributed to research in topics: Embryonic stem cell & Induced pluripotent stem cell. The author has an hindex of 67, co-authored 138 publications receiving 32616 citations. Previous affiliations of Huck-Hui Ng include Agency for Science, Technology and Research & National University of Singapore.
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A biophysical model for analysis of transcription factor interaction and binding site arrangement from genome-wide binding data.
TL;DR: STAP is an effective method to analyze binding site arrangements, TF cooperativity, and TF target genes from genome-wide TF-DNA binding data and shows that prediction of functional TF targets from ChIP-chip data can be improved by using the conservation of STAP predicted affinities as an additional filter.
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A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming.
Yun-Shen Chan,Yun-Shen Chan,Jonathan Göke,Jonathan Göke,Xinyi Lu,Xinyi Lu,Nandini Venkatesan,Bo Feng,I-hsin Su,Huck-Hui Ng +9 more
TL;DR: A repressive role of PRDM 14 is revealed in the maintenance and induction of pluripotency and PRDM14 is identified as a new regulator of PRC2, which is implicated to suppress differentiation genes in human ESCs.
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Zfp143 regulates Nanog through modulation of Oct4 binding.
TL;DR: This study reveals a novel regulator functionally important for the self‐renewal of ES cells and provides new insights into the expanded regulatory circuitry that maintains ES cell pluripotency.
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Molecular framework underlying pluripotency
TL;DR: The molecular framework governing pluripotency is explored in the context of pluripotent ES cells and the reprogrammed iPS cells to explore the molecular mechanisms driving reprogramming.
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p73 supports cellular growth through c-Jun-dependent AP-1 transactivation.
Faina Vikhanskaya,Wen Hong Toh,Iqbal Dulloo,Qiang Wu,Lakshmanane Boominathan,Huck-Hui Ng,Huck-Hui Ng,Karen H. Vousden,Kanaga Sabapathy +8 more
TL;DR: A role for p73 is reported in supporting cellular growth through the upregulation of AP-1 transcriptional activity through which it supports cellular growth.