H
Huck-Hui Ng
Researcher at Genome Institute of Singapore
Publications - 144
Citations - 35090
Huck-Hui Ng is an academic researcher from Genome Institute of Singapore. The author has contributed to research in topics: Embryonic stem cell & Induced pluripotent stem cell. The author has an hindex of 67, co-authored 138 publications receiving 32616 citations. Previous affiliations of Huck-Hui Ng include Agency for Science, Technology and Research & National University of Singapore.
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Journal ArticleDOI
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb
Bo Feng,Jianming Jiang,Jianming Jiang,Petra Kraus,Jia-Hui Ng,Jian-Chien Dominic Heng,Jian-Chien Dominic Heng,Yun-Shen Chan,Yun-Shen Chan,Lai-Ping Yaw,Weiwei Zhang,Weiwei Zhang,Yuin-Han Loh,Yuin-Han Loh,Jianyong Han,Vinsensius B. Vega,Valere Cacheux-Rataboul,Bing Lim,Bing Lim,Thomas Lufkin,Huck-Hui Ng,Huck-Hui Ng +21 more
TL;DR: This work shows that the orphan nuclear receptor Esrrb functions in conjunction with Oct4 and Sox2 to mediate reprogramming of mouse embryonic fibroblasts (MEFs) to iPS cells, and indicates that it is possible to reprogram MEFs without exogenous Klf transcription factors and link a nuclear receptor to somatic cell reprograming.
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Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells
TL;DR: The results connect the ES cell transcription circuitry to chromatin modulation through H3K9 demethylation in pluripotent cells.
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The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells.
Jian-Chien Dominic Heng,Bo Feng,Jianyong Han,Jianming Jiang,Petra Kraus,Jia-Hui Ng,Yuriy L. Orlov,Mikael Huss,Lin Yang,Thomas Lufkin,Thomas Lufkin,Bing Lim,Bing Lim,Huck-Hui Ng,Huck-Hui Ng +14 more
TL;DR: It is shown that the orphan nuclear receptor Nr5a2 (also known as Lrh-1) can replace Oct4 in the derivation of iPSCs from mouse somatic cells, and it can also enhance reprogramming efficiency.
Journal ArticleDOI
Histone deacetylases: silencers for hire.
Huck-Hui Ng,Adrian Bird +1 more
TL;DR: This work has shown that eukaryotic genes can be silenced by deacetylation of acetyl-lysine moieties in the N-terminal tails of histones, and links histoneDeacetylases with an increasing number of repressors, suggesting that deacetylene might be a rather pervasive feature of transcriptional repression systems.
Journal ArticleDOI
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity
Na-Yu Chia,Yun-Shen Chan,Yun-Shen Chan,Bo Feng,Xinyi Lu,Xinyi Lu,Yuriy L. Orlov,Dimitri Moreau,Pankaj Kumar,Lin Yang,Jianming Jiang,Mei-Sheng Lau,Mikael Huss,Boon Seng Soh,Petra Kraus,Pin Li,Thomas Lufkin,Bing Lim,Bing Lim,Neil D. Clarke,Neil D. Clarke,Frederic Bard,Frederic Bard,Huck-Hui Ng +23 more
TL;DR: A genome-wide RNA interference screen to identify genes which regulate self-renewal and pluripotency properties in hESCs uncovers a wealth of novel hESC regulators wherein PRDM14 exemplifies a key transcription factor required for the maintenance of h ESC identity and the reacquisition of pluripOTency in human somatic cells.