Huei Mei Chen

TL;DR: Hyperadenylation may be a general signal for RNA degradation, and inactivation of Mmi1 in meiosis allows meiotic expression, through splicing and RNA stabilization, of at least 29 target genes, which are apparently constitutively transcribed.

TL;DR: Two regulatory elements are located at the 3′ end of the crs1 gene, consistent with the increased accumulation of spliced RNA in polyadenylation factor mutants, which may ensure a rapid response to adverse conditions, thereby guaranteeing survival.

TL;DR: The discovery of a histone methyltransferase complex whose nuclear accumulation and activation establish the onset of heterochromatin formation in Caenorhabditis elegans embryos is reported, and data reveal that nuclear accumulation of MET-2 in conjunction with LIN-65 and ARLE-14 regulates timing of heterchromatin domains during embryogenesis.

TL;DR: It is demonstrated that the “unspliced” signal in vegetative cells comes from the antisense RNA, not from unspliced sense RNA, and it is argued against the idea that splicing regulates these mid-meiotic genes.

TL;DR: Recent studies using different yeasts that reveal a conserved pattern in which meiotically expressed genes have antisense transcripts in vegetative cells.