S
Susan E. Mango
Researcher at University of Basel
Publications - 62
Citations - 6583
Susan E. Mango is an academic researcher from University of Basel. The author has contributed to research in topics: Caenorhabditis elegans & Gene. The author has an hindex of 37, co-authored 60 publications receiving 6222 citations. Previous affiliations of Susan E. Mango include Princeton University & Massachusetts Institute of Technology.
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Journal ArticleDOI
A Map of the Interactome Network of the Metazoan C. elegans
Siming Li,Christopher M. Armstrong,Nicolas Bertin,Hui Ge,Stuart Milstein,Mike Boxem,Pierre-Olivier Vidalain,Jing-Dong J. Han,Alban Chesneau,Tong Hao,Debra S. Goldberg,Ning Li,Monica Martinez,Jean François Rual,Philippe Lamesch,Lai Xu,Lai Xu,Muneesh Tewari,Sharyl L. Wong,Lan V. Zhang,Gabriel F. Berriz,Laurent Jacotot,Philippe Vaglio,Jérôme Reboul,Tomoko Hirozane-Kishikawa,Qian-Ru Li,Harrison W. Gabel,Ahmed Elewa,Ahmed Elewa,Bridget L. Baumgartner,Debra J. Rose,Haiyuan Yu,Stephanie Bosak,Reynaldo Sequerra,Andrew G. Fraser,Susan E. Mango,William M. Saxton,Susan Strome,Sander van den Heuvel,Fabio Piano,Jean Vandenhaute,Claude Sardet,Mark Gerstein,Lynn Doucette-Stamm,Kristin C. Gunsalus,J. Wade Harper,J. Wade Harper,Michael E. Cusick,Frederick P. Roth,David E. Hill,Marc Vidal +50 more
TL;DR: A large fraction of the Caenorhabditis elegans interactome network is mapped, starting with a subset of metazoan-specific proteins, and more than 4000 interactions were identified from high-throughput, yeast two-hybrid screens.
Journal ArticleDOI
The art and design of genetic screens: Caenorhabditis elegans
Erik M. Jorgensen,Susan E. Mango +1 more
TL;DR: The nematode Caenorhabditis elegans was chosen as a model genetic organism because its attributes, chiefly its hermaphroditic lifestyle and rapid generation time, make it suitable for the isolation and characterization of genetic mutants.
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Regulation of organogenesis by the Caenorhabditis elegans FoxA protein PHA-4.
Jeb Gaudet,Susan E. Mango +1 more
TL;DR: The data suggest that PHA-4 directly activates most or all pharyngeal genes, and that direct transcriptional regulation of entire gene networks may be a common feature of organ identity genes.
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Pioneer transcription factors, chromatin dynamics, and cell fate control.
Kenneth S. Zaret,Susan E. Mango +1 more
TL;DR: Understanding how pioneer factors initiate chromatin dynamics and how such can be blocked at heterochromatic sites provides insights into controlling cell fate transitions at will.
Journal ArticleDOI
A gene-centered C. elegans protein-DNA interaction network
Bart Deplancke,Arnab Mukhopadhyay,Wanyuan Ao,Ahmed Elewa,Christian A. Grove,Natalia J. Martinez,Reynaldo Sequerra,Lynn Doucette-Stamm,John S. Reece-Hoyes,Ian A. Hope,Heidi A. Tissenbaum,Susan E. Mango,Albertha J.M. Walhout +12 more
TL;DR: This work uses "gene-centered" high-throughput yeast one-hybrid (Y1H) assays to identify 283 interactions between 72 C. elegans digestive tract gene promoters and 117 proteins, and provides functional annotations for approximately 10% of all worm TFs and finds ten novel putative TFs, illustrating the power of a gene-centered approach.