B
Bruce Futcher
Researcher at Stony Brook University
Publications - 107
Citations - 15411
Bruce Futcher is an academic researcher from Stony Brook University. The author has contributed to research in topics: Cell cycle & Saccharomyces cerevisiae. The author has an hindex of 49, co-authored 102 publications receiving 14835 citations. Previous affiliations of Bruce Futcher include University of Alberta & McMaster University.
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Journal ArticleDOI
Comprehensive Identification of Cell Cycle–regulated Genes of the Yeast Saccharomyces cerevisiae by Microarray Hybridization
Paul T. Spellman,Gavin Sherlock,Gavin Sherlock,Michael Q. Zhang,Vishwanath R. Iyer,Kirk R. Anders,Michael B. Eisen,Patrick O. Brown,Patrick O. Brown,David Botstein,Bruce Futcher +10 more
TL;DR: A comprehensive catalog of yeast genes whose transcript levels vary periodically within the cell cycle is created, and it is found that the mRNA levels of more than half of these 800 genes respond to one or both of these cyclins.
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A sampling of the yeast proteome
TL;DR: It is found that there is an enormous range of protein abundance and, for identified spots, a good correlation between protein abundance, mRNA abundance, and codon bias.
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Human D-type cyclin
TL;DR: A cDNA library prepared from a human glioblastoma cell line has been introduced into a budding yeast strain that lacks CLN1 and CLN2 and is conditionally deficient for CLN3 function and rescued a gene that is called cyclin D1, related to A-, B-, andCLN-type cyclins, but appears to define a new subclass within the cyclin gene family.
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Virus attenuation by genome-scale changes in codon pair bias.
J. Robert Coleman,Dimitris Papamichail,Steven Skiena,Bruce Futcher,Eckard Wimmer,Steffen Mueller +5 more
TL;DR: De novo large DNA molecules are synthesized using hundreds of over-or underrepresented synonymous codon pairs to encode the poliovirus capsid protein and polioviruses containing such amino acid–independent changes were attenuated in mice.
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Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins
TL;DR: It is shown that B-type-cyclin degradation in yeast involves an essential nuclear ubiquitin-conjugating enzyme, UBC9, and that distinct degradation signals or regulated interaction with the ubiquitIn-protein ligase system may determine the cell-cycle specificity of cyclin proteolysi.