H
Hui Hua
Researcher at Sichuan University
Publications - 34
Citations - 1963
Hui Hua is an academic researcher from Sichuan University. The author has contributed to research in topics: Cancer & Protein kinase B. The author has an hindex of 17, co-authored 28 publications receiving 1164 citations.
Papers
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Journal ArticleDOI
Targeting mTOR for cancer therapy
TL;DR: Recent advances in exploring mTOR signaling and the development of mTOR inhibitors for cancer therapy are updated and the mechanisms underlying the resistance to mTOR inhibitor in cancer cells are discussed.
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Matrix metalloproteinases in tumorigenesis: an evolving paradigm.
TL;DR: The complex roles of MMPs and their endogenous inhibitors such as tissue inhibitors of metalloproteinase in tumorigenesis and strategies in suppressing M MPs are reviewed.
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Complex roles of cAMP-PKA-CREB signaling in cancer.
TL;DR: The important roles of cAMP–PKA–CREB signaling in tumorigenesis are highlighted and the potential strategies to target this pathway for cancer therapy are discussed.
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Mechanisms for estrogen receptor expression in human cancer.
TL;DR: The mechanisms underlying the aberrant expression of ER in breast cancer and other types of human tumors are complex, involving considerable alternative splicing of ERα and ERβ, transcription factors, epigenetic and post-transcriptional regulation of ER expression.
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mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR.
Yancun Yin,Hui Hua,Minjing Li,Shu Liu,Qingbin Kong,Ting Shao,Jiao Wang,Yuanming Luo,Qian Wang,Ting Luo,Yangfu Jiang +10 more
TL;DR: It is shown that mTOR possesses unexpected tyrosine kinase activity and activates IGF-IR/InsR, and this work identifies mTOR as a dual-specificity kinase and clarifies how mTORC2 promotes IGF-ir/ InsR activation.