H
Hui Zhang
Researcher at University of Nevada, Las Vegas
Publications - 69
Citations - 11785
Hui Zhang is an academic researcher from University of Nevada, Las Vegas. The author has contributed to research in topics: Ubiquitin ligase & Cyclin-dependent kinase. The author has an hindex of 32, co-authored 63 publications receiving 11384 citations. Previous affiliations of Hui Zhang include Yale University & Cold Spring Harbor Laboratory.
Papers
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Journal ArticleDOI
p21 is a universal inhibitor of cyclin kinases
Yue Xiong,Gregory J. Hannon,Gregory J. Hannon,Hui Zhang,Hui Zhang,David J. Casso,David J. Casso,Ryuji Kobayashi,David Beach,David Beach +9 more
TL;DR: It is found that over expression of p21 inhibits the activity of each member of the cyclin/CDK family, and this results indicate that p21 may be a universal inhibitor of cyclin kinases.
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D Type Cyclins Associate with Multiple Protein Kinases and the DNA Replication and Repair Factor PCNA
Yue Xiong,Hui Zhang,David Beach +2 more
TL;DR: Findings link a human putative G1 cyclin that is associated with oncogenesis with a well-characterized DNA replication and repair factor with a quaternary complex of D cyclin, CDK, PCNA, and p21 and that many combinatorial variations may assemble in vivo.
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PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway
Hong Sun,Ralf Lesche,Da-Ming Li,Joanna Liliental,Hui Zhang,Jing Gao,Nadia Gavrilova,Brenda Mueller,Xin Liu,Hong Wu +9 more
TL;DR: The studies suggest that PTEN regulates the phosphatidylinositol 3,4, 5,-trisphosphate and Akt signaling pathway and consequently modulates two critical cellular processes: cell cycle progression and cell survival.
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p27Kip1 ubiquitination and degradation is regulated by the SCFSkp2 complex through phosphorylated Thr187 in p27
TL;DR: The data suggest that SCF(Skp2) specifically targets p27 for degradation during cell-cycle progression, and indicates that this protein complex is implicated in control of the G1-S transition in the cell cycle.
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p21-containing cyclin kinases exist in both active and inactive states.
TL;DR: It is shown that p21-containing complexes exist in both catalytically active and inactive forms, which challenges the current view that active cyclin kinases function only in the binary state and reveals the subtlety with which tumor-suppressor proteins modulate the cell cycle.