Huib N. Caron

TL;DR: This article summarizes the understanding of neuroblastoma biology and prognostic features and discusses their impact on current and proposed risk stratification schemas, risk-based therapeutic approaches, and the development of novel therapies for patients at high risk for failure.

TL;DR: The parental origin of 1p36 alleles lost in 47 neuroblastomas and a detailed Southern blot analysis of the extent of the 1p deletions in 38 cases strongly suggests that different suppressor genes on 1p are inactivated in these two types of neuroblastoma.

TL;DR: This analysis of neuroblastomas for the N–myc copy number, loss of heterozygosity (LOH) of chromosome 1 p36 and the parental origin of the lost alleles implies that the two alleles of the putative neuroblastoma suppressor gene on chromosome 1p36 are functionally different, depending on their parental origin.

TL;DR: It is demonstrated that only a few of the prognostic factors proposed have been proven to be clinically relevant and age<1 year is a clear and independent prognostic factor for progression-free survival.

TL;DR: In this article, the authors explored the role of cognitive coping in relation to health-related quality of life (HRQoL) in young adult survivors of childhood cancer and found that cognitive coping was the best predictor of the Physical Component Scale of the RAND-36, and cognitive coping contributed almost equally well to the Mental Component Scale.