H
Huib N. Caron
Researcher at University of Amsterdam
Publications - 74
Citations - 10178
Huib N. Caron is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Neuroblastoma & Gene. The author has an hindex of 41, co-authored 72 publications receiving 9388 citations. Previous affiliations of Huib N. Caron include Boston Children's Hospital.
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Journal ArticleDOI
Prevalence and patterns of morphological abnormalities in patients with childhood cancer.
Johannes H. M. Merks,Heval Ozgen,Heval Ozgen,Jan Koster,Aeilko H. Zwinderman,Huib N. Caron,Raoul C.M. Hennekam,Raoul C.M. Hennekam +7 more
TL;DR: Pediatric patients with cancer show a significantly higher prevalence of morphological abnormalities compared with controls, and specific patterns of Morphological abnormalities indicate possible unrecognized tumor predisposition syndromes, but validation in an independent sample is needed.
Journal ArticleDOI
High delta-like 1 expression in a subset of neuroblastoma cell lines corresponds to a differentiated chromaffin cell type.
Vera van Limpt,Alvin Chan,Peter van Sluis,Huib N. Caron,Carel J. M. van Noesel,Rogier Versteeg +5 more
TL;DR: In this article, the Drosophila Delta homologue Dlk1 was identified as one of the genes most highly expressed in the neuroblastoma cell line SK-N-F1.
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Chromosome bands 1p35-36 contain two distinct neuroblastoma tumor suppressor loci, one of which is imprinted.
Huib N. Caron,Nicole Spieker,Marc B. Godfried,Monique Veenstra,Peter van Sluis,Jan de Kraker,P.A. Voûte,Rogier Versteeg +7 more
TL;DR: The results corroborate the existence of two TSGs on 1p and suggest distinct 1p loci seem to be involved in MYCN single copy vs. MYCN amplified neuroblastoma, as these tumors display a different type of shortest region of overlap (SRO).
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Copy number defects of G1‐Cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis
Jan J. Molenaar,Jan Koster,Marli E. Ebus,Peter van Sluis,Ellen M. Westerhout,Katleen De Preter,David Gisselsson,Iingrid Øra,Iingrid Øra,Franki Speleman,Huib N. Caron,Rogier Versteeg +11 more
TL;DR: The findings suggest that pharmacological inhibition of cell cycle genes might bear therapeutic promises for patients with high risk neuroblastoma.
Journal Article
Recurrent 1;17 translocations in human neuroblastoma reveal nonhomologous mitotic recombination during the S/G2 phase as a novel mechanism for loss of heterozygosity.
Huib N. Caron,P. van Sluis,N. Van Roy,J. de Kraker,Franki Speleman,P.A. Voûte,Andries Westerveld,Rosalyn Slater,Rogier Versteeg +8 more
TL;DR: Southern blot and cytogenetic analyses show that in all cases the chromosome 17 homologue from which the 1;17 translocation was derived is still present and intact, suggesting a model in which a translocation between the short arm of chromosomes 1 and the long arm of chromosome 17 takes place in the S/G2 phase of the cell cycle and results in LOH 1p.