Showing papers by "Huige Li published in 2018"
TL;DR: A PON2 redox-dependent mechanism that regulates endothelial cell TF activity and prevents systemic coagulation activation and inflammation is delineated.
40 citations
TL;DR: Noise pollution, mental stresses, and smoking (as a stress-relieving solution) are some environmental hazards that affect well-being and healthcare budgets and dissecting their pathophysiology could lead to solutions to reduce their harmful effects.
Abstract: Significance: Modern technologies have eased our lives but these conveniences can impact our lifestyles in destructive ways. Noise pollution, mental stresses, and smoking (as a stress-relieving solution) are some environmental hazards that affect our well-being and healthcare budgets. Scrutinizing their pathophysiology could lead to solutions to reduce their harmful effects. Recent Advances: Oxidative stress plays an important role in initiating local and systemic inflammation after noise pollution, mental stress, and smoking. Lipid peroxidation and release of lysolipid by-products, disturbance in activation and function of nuclear factor erythroid 2-related factor 2 (Nrf2), induction of stress hormones and their secondary effects on intracellular kinases, and dysregulation of intracellular Ca2+ can all potentially trigger other vicious cycles. Recent clinical data suggest that boosting the antioxidant system through nonpharmacological measures, for example, lifestyle changes that include exercis...
37 citations
TL;DR: In this article, the authors present a paper based upon work from COST Action 603 (EU-ROS), supported by COST (European Cooperation in======Science and Technology) which is funded by the Horizon 2020Framework Programme of the European Union.
Abstract: This article/publication is based upon work from COST Action
BM1203 (EU-ROS), supported by COST (European Cooperation in
Science and Technology) which is funded by the Horizon 2020
Framework Programme of the European Union. COST (European
Cooperation in Science and Technology) is a funding agency for research
and innovation networks.
11 citations
TL;DR: It is shown for the first time that RFO stimulated the phosphorylation of the endothelial nitric oxide synthase (eNOS) and enhanced the NO production in human endothelial cells and significantly decreased oxidative DNA damage induced by genotoxicants.
9 citations
TL;DR: This work calls for an immediate revision of the death determination criteria in execution by lethal injection in China, arguing that biological death must be ensured before death pronouncement, regardless of whether organ procurement is involved or not.
Abstract: Since 1997, execution in China has been increasingly performed by lethal injection. The current criteria for determination of death for execution by lethal injection (cessation of heartbeat, cessation of respiration, and dilated pupils) neither conform to current medical science nor to any standard of medical ethics. In practice, death is pronounced in China within tens of seconds after starting the lethal injection. At this stage, however, neither the common criteria for cardiopulmonary death (irreversible cessation of heartbeat and breathing) nor that of brain death (irreversible cessation of brain functions) have been met. To declare a still-living person dead is incompatible with human dignity, regardless of the processes following death pronouncement. This ethical concern is further aggravated if organs are procured from the prisoners. Analysis of postmortem blood thiopental level data from the United States indicates that thiopental, as used, may not provide sufficient surgical anesthesia. The dose of thiopental used in China is kept secret. It cannot be excluded that some of the organ explantation surgeries on prisoners subjected to lethal injection are performed under insufficient anesthesia in China. In such cases, the inmate may potentially experience asphyxiation and pain. Yet this can be easily overlooked by the medical professionals performing the explantation surgery because pancuronium prevents muscle responses to pain, resulting in an extremely inhumane situation. We call for an immediate revision of the death determination criteria in execution by lethal injection in China. Biological death must be ensured before death pronouncement, regardless of whether organ procurement is involved or not.
1 citations