H
Huimin Lu
Researcher at Chinese Academy of Sciences
Publications - 12
Citations - 271
Huimin Lu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Colitis & Proinflammatory cytokine. The author has an hindex of 6, co-authored 12 publications receiving 104 citations.
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Journal ArticleDOI
Protective role of berberine on ulcerative colitis through modulating enteric glial cells-intestinal epithelial cells-immune cells interactions.
Heng Li,Chen Fan,Huimin Lu,Chunlan Feng,Pei-Lan He,Xiaoqian Yang,Caigui Xiang,Jianping Zuo,Jianping Zuo,Wei Tang +9 more
TL;DR: The study indicated the EGCs–IECs–immune cell interactions might function as a crucial paradigm in mucosal inflammation and provided an infusive mechanism of berberine in regulating enteric neurogenic inflammation.
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Inhibition of phosphodiesterase-4 attenuates murine ulcerative colitis through interference with mucosal immunity.
Heng Li,Chen Fan,Chunlan Feng,Yanwei Wu,Huimin Lu,Pei-Lan He,Xiaoqian Yang,Fenghua Zhu,Qing Qi,Yuanzhuo Gao,Jianping Zuo,Wei Tang +11 more
TL;DR: This study was designed to explore whether PDE4 inhibition by apremilast exerts protective effects in dextran sulfate sodium‐induced murine UC.
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Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis
Heng Li,Chunlan Feng,Chen Fan,Yang Yang,Xiaoqian Yang,Huimin Lu,Qiukai Lu,Fenghua Zhu,Caigui Xiang,Zongwang Zhang,Pei-Lan He,Jianping Zuo,Jianping Zuo,Wei Tang +13 more
TL;DR: Berberine significantly attenuated the experimental symptoms and gut inflammation of chronic UC and illustrated that OSM and OSMR intervention might function as the potential target in chronic UC.
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Heme protects intestinal mucosal barrier in DSS-induced colitis through regulating macrophage polarization in both HO-1-dependent and HO-1-independent way
Yanwei Wu,Bing Wu,Zongwang Zhang,Huimin Lu,Chen Fan,Qing Qi,Yuanzhuo Gao,Heng Li,Chunlan Feng,Jianping Zuo,Wei Tang +10 more
TL;DR: Results showed that the modification of colon tissue microenvironment with heme supplementation plays a protective role in DSS‐induced colitis mice through regulating the macrophage polarization in both HO‐1‐dependent and HO‐ 1‐independent way, indicating a new choice to therapeutically modulate the macophage function and prevent IBD.
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DZ2002 ameliorates fibrosis, inflammation, and vasculopathy in experimental systemic sclerosis models.
Zongwang Zhang,Yanwei Wu,Bing Wu,Qing Qi,Heng Li,Huimin Lu,Chen Fan,Chunlan Feng,Jianping Zuo,Lili Niu,Wei Tang +10 more
TL;DR: Investigations showed that DZ2002 relieved systemic sclerosis by regulating fibrosis TGF-β/Smad signaling pathway and would be a potential drug for the treatment of systemic sclerosis.