Huiyun Lin

TL;DR: In this review, United States Food and Drug Administration 510(k) cleared commercial systems and some leading premarket FGS research systems were evaluated to illustrate the continual increase in this performance feature base.

TL;DR: A method that uses thin sheets of X-ray radiation to generate emissions of Cherenkov luminescence can image an oxygen-sensitive molecular probe to map oxygenation in tumours in vivo at submillimetre resolution and nanomolar sensitivity.

TL;DR: This paradigm of nanoMolar sensitivity for optical reporters in vivo introduces the concept of molecular sensing of tumors during therapy or diagnostically with biologically relevant concentrations of fluorescent reporters.

TL;DR: High-resolution imaging of tissue-equivalent phantoms up to 3 cm thick is demonstrated using a radiotherapy linear accelerator, yielding the precise position and shape of luminescent lesions located deep in tissue without the need for nonlinear image reconstruction.

TL;DR: It is observed that fluorescence emissions excited by the Cherenkov signal produced within the phantom could be detected at 5-mm depth into the media within a 0.1–25 μM fluorophore concentration range, suggesting that these could be used for metabolic probes in vivo where the local concentrations are near this range.