H
Humi Imaki
Publications - 18
Citations - 1693
Humi Imaki is an academic researcher. The author has contributed to research in topics: Autism & Microglia. The author has an hindex of 12, co-authored 18 publications receiving 1550 citations.
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Journal ArticleDOI
Contribution of glial cells to the development of amyloid plaques in Alzheimer’s disease
TL;DR: These results highlight the therapeutic potential of blocking the initial intracellular accumulation of Abeta42 in neurons and astrocytes and inhibiting microglia-mediated assembly of fibrillar Abeta, which is particularly resistant to degradation in Alzheimer brain.
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The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes
Jerzy Wegiel,Izabela Kuchna,Krzysztof Nowicki,Humi Imaki,Jarek Wegiel,Elaine Marchi,Shuang Yong Ma,Abha Chauhan,Ved Chauhan,Teresa Wierzba Bobrowicz,Mony J. de Leon,Mony J. de Leon,Leslie A. Saint Louis,Ira L. Cohen,Eric London,W. Ted Brown,Thomas Wisniewski +16 more
TL;DR: Deterioration in the patterns of focal qualitative developmental defects in the brains of autistic subjects reflects multiregional dysregulation of neurogenesis, neuronal migration and maturation in autism, which may contribute to the heterogeneity of the clinical phenotype.
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The role of microglial cells and astrocytes in fibrillar plaque evolution in transgenic APPSW mice
Jerzy Wegiel,Kuo-Chiang Wang,Humi Imaki,Richard Rubenstein,Anetta Wronska,Marcin F. Osuchowski,William J. Lipinski,Larry C Walker,Harry LeVine +8 more
TL;DR: The study suggests that microglial cells are not engaged in Abeta removal and plaque degradation, but in contrast, are a driving force in plaque formation and development.
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Stereological study of the neuronal number and volume of 38 brain subdivisions of subjects diagnosed with autism reveals significant alterations restricted to the striatum, amygdala and cerebellum.
Jerzy Wegiel,Michael Flory,Izabela Kuchna,Krzysztof Nowicki,Shuang Yong Ma,Humi Imaki,Jarek Wegiel,Ira L. Cohen,Eric London,Thomas Wisniewski,W T Brown +10 more
TL;DR: The observed pattern of developmental alterations in the cerebellum, amygdala and striatum is consistent with the results of magnetic resonance imaging studies and their clinical correlations, and of some morphometric studies that indicate that detected abnormalities may contribute to the social and communication deficits, and repetitive and stereotypical behaviors observed in individuals with autism.
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Intraneuronal Aβ immunoreactivity is not a predictor of brain amyloidosis-β or neurofibrillary degeneration
Jerzy Wegiel,Izabela Kuchna,Krzysztof Nowicki,Janusz Frackowiak,Bozena Mazur-Kolecka,Humi Imaki,Jarek Wegiel,Pankaj Mehta,Wayne Silverman,Barry Reisberg,Mony deLeon,Thomas Wisniewski,Tuula Pirttilla,H. Frey,Terho Lehtimäki,Tarmo Kivimaki,Frank E. Visser,Wouter Kamphorst,Anna Potempska,David C. Bolton,Julia R. Currie,David Miller +21 more
TL;DR: The constant level of Aβ immunoreactivity in structures free from neuronal pathology during essentially the entire life span suggests that intraneuronal amino-terminally truncated Aβ represents a product of normal neuronal metabolism.