M
Marcin F. Osuchowski
Researcher at Boston University
Publications - 77
Citations - 3993
Marcin F. Osuchowski is an academic researcher from Boston University. The author has contributed to research in topics: Sepsis & Medicine. The author has an hindex of 25, co-authored 69 publications receiving 3195 citations. Previous affiliations of Marcin F. Osuchowski include University of Michigan & University of Georgia.
Papers
More filters
Journal ArticleDOI
The Pathogenesis of Sepsis
Deborah J. Stearns-Kurosawa,Marcin F. Osuchowski,Catherine Valentine,Shinichiro Kurosawa,Daniel G. Remick +4 more
TL;DR: Biomarkers may be used to help diagnose patients with sepsis, and they may also help to identify patients who would benefit from immunomodulatory therapies.
Journal ArticleDOI
Circulating Cytokine/Inhibitor Profiles Reshape the Understanding of the SIRS/CARS Continuum in Sepsis and Predict Mortality
TL;DR: It is demonstrated that the initial inflammatory response directly correlates to early but not late sepsis mortality, and this multifaceted response questions the use of a simple proinflammatory cytokine measurement for classifying the inflammatory status during septis.
Journal ArticleDOI
Sepsis: Multiple Abnormalities, Heterogeneous Responses, and Evolving Understanding
Kendra N. Iskander,Marcin F. Osuchowski,Deborah J. Stearns-Kurosawa,Shinichiro Kurosawa,David Stepien,Catherine Valentine,Daniel G. Remick +6 more
TL;DR: Given the complexity of sepsis, biomarkers and mathematical models offer potential guidance once they have been carefully validated to provide a framework for understanding the complex and current challenges of managing the septic patient.
Journal ArticleDOI
The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity.
Marcin F. Osuchowski,Martin Sebastian Winkler,Tomasz Skirecki,Sara Cajander,Manu Shankar-Hari,Manu Shankar-Hari,Gunnar Lachmann,Guillaume Monneret,Fabienne Venet,Michael Bauer,Frank M. Brunkhorst,Sebastian Weis,Alberto García-Salido,Matthijs Kox,Jean-Marc Cavaillon,Florian Uhle,Markus A. Weigand,Stefanie B. Flohé,W. Joost Wiersinga,Raquel Almansa,Amanda de la Fuente,Ignacio Martin-Loeches,Christian Meisel,Thibaud Spinetti,Joerg C. Schefold,Catia Cilloniz,Antoni Torres,Antoni Torres,Evangelos J. Giamarellos-Bourboulis,Ricard Ferrer,Ricard Ferrer,Massimo Girardis,Andrea Cossarizza,Mihai G. Netea,Mihai G. Netea,Mihai G. Netea,Tom van der Poll,Jesus F. Bermejo-Martin,Ignacio Rubio +38 more
TL;DR: The authors reviewed the intricacies of COVID-19 pathophysiology, its various phenotypes, and the anti-SARS-CoV-2 host response at the humoral and cellular levels.
Journal ArticleDOI
Current gaps in sepsis immunology: new opportunities for translational research.
Ignacio Rubio,Marcin F. Osuchowski,Manu Shankar-Hari,Manu Shankar-Hari,Tomasz Skirecki,Martin Sebastian Winkler,Gunnar Lachmann,Paul La Rosée,Guillaume Monneret,Fabienne Venet,Michael Bauer,Frank M. Brunkhorst,Matthijs Kox,Jean-Marc Cavaillon,Florian Uhle,Markus A. Weigand,Stefanie B. Flohé,W. Joost Wiersinga,Marta Martín-Fernández,Raquel Almansa,Raquel Almansa,Ignacio Martin-Loeches,Antoni Torres,Antoni Torres,Evangelos J. Giamarellos-Bourboulis,Massimo Girardis,Andrea Cossarizza,Mihai G. Netea,Mihai G. Netea,Mihai G. Netea,Tom van der Poll,André Scherag,Christian Meisel,Joerg C. Schefold,Jesus F. Bermejo-Martin,Jesus F. Bermejo-Martin +35 more
TL;DR: The role of key immune cells, the cause of lymphopenia, organ-specific immunology, the dynamics of sepsis-associated immunological alterations, the role of the microbiome, the standardisation of immunological tests, the development of better animal models, and the opportunities offered by immunotherapy are discussed.