H
Hyang Mi Lee
Researcher at Genentech
Publications - 2
Citations - 410
Hyang Mi Lee is an academic researcher from Genentech. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 2, co-authored 2 publications receiving 203 citations.
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Journal ArticleDOI
Peripheral T cell expansion predicts tumour infiltration and clinical response
Thomas D. Wu,Shravan Madireddi,Patrícia de Almeida,Romain Banchereau,Ying-Jiun J. Chen,Avantika S. Chitre,Eugene Y. Chiang,Hina Iftikhar,William E. O'Gorman,Amelia Au-Yeung,Chikara Takahashi,Leonard D. Goldstein,Chungkee Poon,Shilpa Keerthivasan,Denise E. de Almeida Nagata,Xiangnan Du,Hyang Mi Lee,Karl L. Banta,Sanjeev Mariathasan,Meghna Das Thakur,Mahrukh Huseni,Marcus Ballinger,Ivette Estay,Patrick Caplazi,Zora Modrusan,Lélia Delamarre,Ira Mellman,Richard Bourgon,Jane L. Grogan +28 more
TL;DR: Large-scale single-cell sequencing of RNA and T cell receptors in samples from patients with cancer shows clonotypic expansion of effector-like T cells not only in tumour tissue but also in normal adjacent tissues and peripheral blood, which associates with clinical response to cancer immunotherapy.
Journal ArticleDOI
The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function.
Sairy Hernandez,Jing Qing,Rebecca Hong Thibodeau,Xiangnan Du,Summer Park,Hyang Mi Lee,Min Xu,Soyoung Oh,Armando Navarro,Meron Roose-Girma,Robert J. Newman,Søren Warming,Michelle Nannini,Deepak Sampath,Jeong M. Kim,Jane L. Grogan,Ira Mellman +16 more
TL;DR: The importance of HPK1 kinase activity in the negative regulation of CD8 effector functions is identified, implicating its potential as a cancer immunotherapy target.