S
Shravan Madireddi
Researcher at Genentech
Publications - 24
Citations - 1375
Shravan Madireddi is an academic researcher from Genentech. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 13, co-authored 22 publications receiving 920 citations. Previous affiliations of Shravan Madireddi include La Jolla Institute for Allergy and Immunology & University of Louisville.
Papers
More filters
Journal ArticleDOI
Peripheral T cell expansion predicts tumour infiltration and clinical response
Thomas D. Wu,Shravan Madireddi,Patrícia de Almeida,Romain Banchereau,Ying-Jiun J. Chen,Avantika S. Chitre,Eugene Y. Chiang,Hina Iftikhar,William E. O'Gorman,Amelia Au-Yeung,Chikara Takahashi,Leonard D. Goldstein,Chungkee Poon,Shilpa Keerthivasan,Denise E. de Almeida Nagata,Xiangnan Du,Hyang Mi Lee,Karl L. Banta,Sanjeev Mariathasan,Meghna Das Thakur,Mahrukh Huseni,Marcus Ballinger,Ivette Estay,Patrick Caplazi,Zora Modrusan,Lélia Delamarre,Ira Mellman,Richard Bourgon,Jane L. Grogan +28 more
TL;DR: Large-scale single-cell sequencing of RNA and T cell receptors in samples from patients with cancer shows clonotypic expansion of effector-like T cells not only in tumour tissue but also in normal adjacent tissues and peripheral blood, which associates with clinical response to cancer immunotherapy.
Journal ArticleDOI
TNF superfamily in inflammatory disease: translating basic insights.
TL;DR: Current data show that TNFSF ligand-receptor signaling pathways are active in inflammatory and autoimmune disease, and several genetic polymorphisms in TNFSf and TNFRSF associate with susceptibility to developing disease.
Journal ArticleDOI
High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade.
Kobe C. Yuen,Li-Fen Liu,Vinita Gupta,Shravan Madireddi,Shilpa Keerthivasan,Congfen Li,Deepali Rishipathak,Patrick Williams,Edward E. Kadel,Hartmut Koeppen,Ying-Jiun Chen,Zora Modrusan,Jane L. Grogan,Romain Banchereau,Ning Leng,A. Thåström,X. Shen,Kenji Hashimoto,Darren Tayama,Michiel S. van der Heijden,Jonathan E. Rosenberg,David F. McDermott,Thomas Powles,Priti S. Hegde,Mahrukh Huseni,Sanjeev Mariathasan +25 more
TL;DR: Increased baseline peripheral and tumor IL-8 levels were associated with worse clinical outcomes in patients with metastatic urothelial carcinoma and metastatic renal cell carcinoma treated with anti-PD-L1 therapy.
Journal ArticleDOI
Galectin-9 controls the therapeutic activity of 4-1BB–targeting antibodies
Shravan Madireddi,So-Young Eun,Seung-Woo Lee,Ivana Nemčovičová,Amit Mehta,Dirk M. Zajonc,Nozomu Nishi,Toshiro Niki,Mitsuomi Hirashima,Michael Croft +9 more
TL;DR: Agonistic anti–4-1BB suppresses autoimmune and allergic inflammation via binding to Galectin-9, which facilitates 4-1 BB aggregation, signaling, and functional activity.
Journal Article
Targeting CD4+CD25+FoxP3+ regulatory T-cells for the augmentation of cancer immunotherapy.
TL;DR: In this paper, the molecular basis of Treg cell interaction with tumor cells and ensuing immunosuppressive mechanisms was studied using various approaches, with encouraging preclinical and clinical findings.