Hyo Sun Jin

TL;DR: It is shown that 1,25-dihydroxyvitamin D3 (1,25D3), the active form of vitamin D, induced autophagy in human monocytes via cathelicidin, which activated transcription of the autophophagy-related genes Beclin-1 and Atg5.

TL;DR: It is reported that Mtb Eis plays essential roles in modulating macrophage autophagy, inflammatory responses, and cell death via a reactive oxygen species (ROS)-dependent pathway and suppresses host innate immune defenses by modulating autophagic activation and cytokine production.

TL;DR: In this paper, the authors showed that the enhanced intracellular survival (eis) gene of Mycobacterium tuberculosis (Mtb) plays essential roles in modulating macrophage autophagy, inflammatory responses and cell death via a reactive oxygen species (ROS)-dependent pathway.

TL;DR: It is demonstrated that isoniazid and pyrazinamide promote autophagy activation and phagosomal maturation in Mycobacterium tuberculosis (Mtb)-infected host cells and dampened Mtb-induced proinflammatory responses in macrophages, underscoring the importance of host autphagy in orchestrating successful antimicrobial responses to mycobacteria during chemotherapy.

TL;DR: A previously unrecognized role for SHP is identified as an intrinsic negative regulator of Toll-like receptor (TLR)-triggered inflammatory responses and SHP-deficient mice were more susceptible to endotoxin-induced sepsis.