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I-Ju Liu
Researcher at Academia Sinica
Publications - 19
Citations - 1670
I-Ju Liu is an academic researcher from Academia Sinica. The author has contributed to research in topics: Epitope & Antibody. The author has an hindex of 9, co-authored 19 publications receiving 925 citations. Previous affiliations of I-Ju Liu include National Defense Medical Center & National Taiwan University.
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Development of therapeutic antibodies for the treatment of diseases
TL;DR: The preeminent antibody engineering technologies used in the development of therapeutic antibody drugs, such as humanization of monoclonal antibodies, phage display, the human antibody mouse, single B cell antibody technology, and affinity maturation are outlined.
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Advancement and applications of peptide phage display technology in biomedical science
TL;DR: The latest technological advancements in the application of phage-displayed peptide libraries to applied biomedical sciences are summarized.
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Molecular Mimicry of Human Endothelial Cell Antigen by Autoantibodies to Nonstructural Protein 1 of Dengue Virus
TL;DR: DB16-1 targeted the same epitope in DV NS1 and LYRIC protein on human endothelial cells, suggesting that it might play a role in the pathogenesis of DHF/DSS.
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Analysis of epitopes on dengue virus envelope protein recognized by monoclonal antibodies and polyclonal human sera by a high throughput assay.
Hong-En Lin,Wen-Yang Tsai,I-Ju Liu,Pi-Chun Li,Mei-Ying Liao,Jih-Jin Tsai,Yi-Chieh Wu,Chih-Yun Lai,Chih-Hsuan Lu,Jyh-Hsiung Huang,Gwong-Jen J. Chang,Han-Chung Wu,Wei-Kung Wang,Wei-Kung Wang +13 more
TL;DR: A dot blot assay is developed by using 67 alanine mutants of predicted surface-exposed E residues as a systematic approach to identify epitopes recognized by mAbs and polyclonal sera, which would further the understanding of humoral immune responses to DENV at the epitope level.
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Extracellular domain of EpCAM enhances tumor progression through EGFR signaling in colon cancer cells.
Kang-Hao Liang,Hsien-Cheng Tso,Shao-Hsi Hung,I.-I. Kuan,Jun-Kai Lai,Feng-Yi Ke,Yi-Ting Chuang,I-Ju Liu,Yi Ping Wang,Ruey-Hwa Chen,Han-Chung Wu,Han-Chung Wu +11 more
TL;DR: Analysis of colorectal cancer tissues showed that nuclear accumulation of EpICD was highly correlated with metastasis and poor prognosis, suggesting that it may play an important functional role in cancer progression.