Journal ArticleDOI
Extracellular domain of EpCAM enhances tumor progression through EGFR signaling in colon cancer cells.
Kang-Hao Liang,Hsien-Cheng Tso,Shao-Hsi Hung,I.-I. Kuan,Jun-Kai Lai,Feng-Yi Ke,Yi-Ting Chuang,I-Ju Liu,Yi Ping Wang,Ruey-Hwa Chen,Han-Chung Wu,Han-Chung Wu +11 more
Reads0
Chats0
TLDR
Analysis of colorectal cancer tissues showed that nuclear accumulation of EpICD was highly correlated with metastasis and poor prognosis, suggesting that it may play an important functional role in cancer progression.About:
This article is published in Cancer Letters.The article was published on 2018-10-01. It has received 46 citations till now. The article focuses on the topics: Epithelial cell adhesion molecule & Tumor progression.read more
Citations
More filters
Journal ArticleDOI
Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years?
TL;DR: EpCAM represents a marker for the epithelial status of primary and systemic tumor cells and emerges as a measure for the metastatic capacity of CTCs, which are considered the major source for metastatic cancer cells.
Journal ArticleDOI
Biology and clinical relevance of EpCAM.
TL;DR: The current knowledge on the biological properties of EpCAM is summarized with emphasis on mechanisms involved in cancer progression and the clinical implications of these findings for the clinical use ofEpCAM as a diagnostic marker are discussed.
Journal ArticleDOI
Targeting Autophagy for Overcoming Resistance to Anti-EGFR Treatments.
TL;DR: Whether autophagy inhibition, along with anti-EGFR treatments, might represent a promising approach to overcome resistance to anti- EGFR treatments in various cancers is assessed.
Journal ArticleDOI
Epithelial Cell Adhesion Molecule: An Anchor to Isolate Clinically Relevant Circulating Tumor Cells
TL;DR: The most significant advantages and disadvantages of using EpCAM as a marker for CTC enrichment and its potential biological role in the metastatic cascade are summarized.
Journal ArticleDOI
Expression of the potential therapeutic target claudin-18.2 is frequently decreased in gastric cancer: results from a large Caucasian cohort study
TL;DR: It is concluded that a rather low overall expression rate of CLDN18.2 challenges its significance in advanced GC therapy and indicates the need for further investigations across different populations.
References
More filters
Journal ArticleDOI
Identification and expansion of human colon-cancer-initiating cells
Lucia Ricci-Vitiani,Dario Giuseppe Lombardi,Emanuela Pilozzi,Mauro Biffoni,Matilde Todaro,Cesare Peschle,Ruggero De Maria +6 more
TL;DR: It is concluded that colorectal cancer is created and propagated by a small number of undifferentiated tumorigenic CD133+ cells, which should therefore be the target of future therapies.
Journal ArticleDOI
Isolation of rare circulating tumour cells in cancer patients by microchip technology.
Sunitha Nagrath,Lecia V. Sequist,Shyamala Maheswaran,Daphne W. Bell,Daphne W. Bell,Daniel Irimia,Lindsey Ulkus,Matthew R. Smith,Eunice L. Kwak,Subba R. Digumarthy,Alona Muzikansky,Paula D. Ryan,Ulysses J. Balis,Ulysses J. Balis,Ronald G. Tompkins,Daniel A. Haber,Mehmet Toner +16 more
TL;DR: The CTC-chip successfully identified CTCs in the peripheral blood of patients with metastatic lung, prostate, pancreatic, breast and colon cancer in 115 of 116 samples, with a range of 5–1,281CTCs per ml and approximately 50% purity.
Journal ArticleDOI
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
TL;DR: This review will provide potential mechanistic explanations for the association between EMT induction and the emergence of CSCs, and highlight recent studies implicating the function of TGF-β-regulated noncoding RNAs in driving EMT and promoting CSC self-renewal.
Journal ArticleDOI
Phenotypic characterization of human colorectal cancer stem cells
Piero Dalerba,Scott J. Dylla,In-Kyung Park,Rui Liu,Xinhao Wang,Robert W. Cho,Timothy Hoey,Austin L. Gurney,Emina Huang,Diane M. Simeone,Andrew A. Shelton,Giorgio Parmiani,Chiara Castelli,Michael F. Clarke +13 more
TL;DR: The results validate the stem cell working model in human CRC and provide a highly robust surface marker profile for CRC stem cell isolation.
Journal ArticleDOI
Epidermal growth factor receptor (EGFR) signaling in cancer
Nicola Normanno,Antonella De Luca,Caterina Bianco,Luigi Strizzi,Mario Mancino,Monica R. Maiello,Adele Carotenuto,Gianfranco De Feo,Francesco Caponigro,David S. Salomon +9 more
TL;DR: The growth and the survival of carcinoma cells appear to be sustained by a network of receptors/ligands of the ErbB family, which is important for therapeutic approaches, since the response to anti-EGFR agents might depend on the total level of expression ofErbB receptors and ligands in tumor cells.