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Iain Chambers
Researcher at James Cook University Hospital
Publications - 52
Citations - 1655
Iain Chambers is an academic researcher from James Cook University Hospital. The author has contributed to research in topics: Cerebral perfusion pressure & Intracranial pressure. The author has an hindex of 21, co-authored 51 publications receiving 1475 citations. Previous affiliations of Iain Chambers include Newcastle University.
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Visualizing the pressure and time burden of intracranial hypertension in adult and paediatric traumatic brain injury
Fabian Güiza,Bart Depreitere,Ian Piper,Giuseppe Citerio,Iain Chambers,Patricia A. Jones,T.Y.M. Lo,Per Enblad,Pelle Nillson,Bart Feyen,Philippe G. Jorens,Andrew I R Maas,Martin U. Schuhmann,Rob Donald,Laura Moss,Greet Van den Berghe,Geert Meyfroidt +16 more
TL;DR: The colour-coded plot illustrates the intuitive concept that episodes of higher intracranial pressure can only be tolerated for shorter durations: the curve that delineates the duration and intensity of those intrac Cranial pressure episodes associated with worse outcome is an approximately exponential decay curve.
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Determination of threshold levels of cerebral perfusion pressure and intracranial pressure in severe head injury by using receiver-operating characteristic curves: an observational study in 291 patients.
TL;DR: To establish which one (ICP or CPP) is more predictive of outcome and to examine whether there are significant threshold levels in the determination of outcome, receiver-operating characteristic (ROC) curves were used to analyze data in a large series of head-injured patients.
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Experimental Stroke and Neuroprotection in the Aging Rat Brain
TL;DR: A model of occlusive stroke in the aging rat brain has been developed and used to establish the effects of age on cerebral infarction and to evaluate the scope for protecting the aging brain during ischemia, and NMDA receptor antagonism was neuroprotective in the Aging brain.
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Critical thresholds of intracranial pressure and cerebral perfusion pressure related to age in paediatric head injury
Iain Chambers,PA Jones,T.Y.M. Lo,Rob Forsyth,B Fulton,Peter J. D. Andrews,A. D. Mendelow,Robert A. Minns +7 more
TL;DR: The PTI is the first substantive paediatric index of total ICP and CPP following head injury and had a very high predictive value for outcome and was more predictive than for ICP.
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Assessment of cerebrospinal fluid outflow resistance.
Anders Eklund,Peter Smielewski,Iain Chambers,Noam Alperin,Jan Malm,Marek Czosnyka,Anthony Marmarou +6 more
TL;DR: Distinction between normal pressure hydrocephalus and differential diagnoses, prediction of clinical response to shunting and the possibility of assessment of shunt function in vivo are the three most important applications of infusion studies in clinical practice.