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Iain MacPhee
Researcher at St George's, University of London
Publications - 98
Citations - 4025
Iain MacPhee is an academic researcher from St George's, University of London. The author has contributed to research in topics: Transplantation & Tacrolimus. The author has an hindex of 28, co-authored 98 publications receiving 3461 citations. Previous affiliations of Iain MacPhee include St George's Hospital & University of Oxford.
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Journal ArticleDOI
The Influence of Pharmacogenetics on the Time to Achieve Target Tacrolimus Concentrations after Kidney Transplantation
Iain MacPhee,Salim Fredericks,Tracy Tai,Petros Syrris,Nicholas D. Carter,Atholl Johnston,Lawrence Goldberg,David W. Holt +7 more
TL;DR: An initial dosing regimen for tacrolimus based on knowledge of the CYP3AP1 genotype and subsequently guided by concentration measurements has the potential to increase the proportion of patients achieving target blood concentrations early after transplantation.
Journal Article
The role of the neuroendocrine system in determining genetic susceptibility to experimental allergic encephalomyelitis in the rat.
TL;DR: It is shown that PVG rats that had been adrenalectomized developed severe disease from which they do not recover, and resistance to the induction of EAE could not be abrogated by adrenalectomy in all strains of rats studied.
Journal ArticleDOI
Tacrolimus pharmacogenetics: the CYP3A5*1 allele predicts low dose-normalized tacrolimus blood concentrations in whites and South Asians.
Iain MacPhee,Salim Fredericks,Maha Mohamed,Michelle Moreton,Nicholas D. Carter,Atholl Johnston,Lawrence Goldberg,David W. Holt +7 more
TL;DR: Determination of the CYP3A5*1/*3 genotype could be used to predict the tacrolimus dose requirement and, given incomplete linkage, would be better than determination of the CyP3AP1 genotype.
Journal ArticleDOI
Biomarkers of Tolerance in Kidney Transplantation: Are We Predicting Tolerance or Response to Immunosuppressive Treatment?
Irene Rebollo-Mesa,Irene Rebollo-Mesa,Estefania Nova-Lamperti,Paula Mobillo,Manohursingh Runglall,Sofia Christakoudi,S. Norris,S. Norris,N. Smallcombe,Yogesh Kamra,Rachel Hilton,Sunil Bhandari,Richard J. Baker,David Berglund,Sue Carr,David Game,Sian Griffin,Philip A Kalra,Robert Lewis,Patrick B. Mark,Stephen D. Marks,Iain MacPhee,William McKane,Markus G. Mohaupt,Ravi Pararajasingam,Sui Phin Kon,Daniel Serón,Manish D. Sinha,Beatriz Tucker,Ondrej Viklický,Robert I. Lechler,Robert I. Lechler,Graham M. Lord,Graham M. Lord,Graham M. Lord,Maria P. Hernandez-Fuentes,Maria P. Hernandez-Fuentes,Maria P. Hernandez-Fuentes +37 more
TL;DR: A validated and highly accurate gene expression signature is reported that can be reliably used to identify patients suitable for IS reduction (approximately 12% of stable patients), irrespective of the IS drugs they are receiving.
Journal ArticleDOI
A renal registry for Africa: first steps
M. Razeen Davids,John B. Eastwood,Neville H. Selwood,Fatiu A Arogundade,Gloria Ashuntantang,Mohammed Benghanem Gharbi,Faical Jarraya,Iain MacPhee,Mignon McCulloch,Jacob Plange-Rhule,Charles R. Swanepoel,Dwomoa Adu +11 more
TL;DR: The elements needed for a successful renal registry are reviewed and an overview of renal registries in developed and developing countries are given and the proposed African Renal Registry is discussed, with the emphasis on Africa.