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Ian C. Summerhayes
Researcher at Lahey Hospital & Medical Center
Publications - 78
Citations - 5634
Ian C. Summerhayes is an academic researcher from Lahey Hospital & Medical Center. The author has contributed to research in topics: Bladder cancer & Cell culture. The author has an hindex of 38, co-authored 78 publications receiving 5491 citations. Previous affiliations of Ian C. Summerhayes include National Institutes of Health & Harvard University.
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Journal ArticleDOI
Identification of p53 gene mutations in bladder cancers and urine samples
David Sidransky,Andrew C. von Eschenbach,Yvonne C. Tsai,Peter A. Jones,Ian C. Summerhayes,Fray F. Marshall,Meera Paul,Pearl A Green,Stanley R. Hamilton,Philip Frost,Bert Vogelstein +10 more
TL;DR: The p53 mutations are the first genetic alterations demonstrated to occur in a high proportion of primary invasive bladder cancers, and Detection of such mutations ex vivo has clinical implications for monitoring individuals whose tumor cells are shed extracorporeally.
Journal ArticleDOI
Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells.
Ian C. Summerhayes,Theodore J. Lampidis,Samuel D. Bernal,John J. Nadakavukaren,Karen K. Nadakavukaren,Elizabeth L. Shepherd,Lan Bo Chen +6 more
TL;DR: Mitochondria in cardiac muscle cells and myoblast-fused myotubes display unusually long retention times of rhodamine 123, a mitochondria-specific fluorescent probe, in living cells, and the presence of mitochondria having unusual dye retention may be useful for diagnosis and exploitable for chemotherapy of certain human carcinomas.
Journal ArticleDOI
The DCC Protein and Prognosis in Colorectal Cancer
David Shibata,Michael A. Reale,Philip T. Lavin,Mark L. Silverman,Eric R. Fearon,Glenn Steele,J. M. Jessup,Massimo Loda,Ian C. Summerhayes +8 more
TL;DR: In stage II colorectal carcinomas, the absence of DCC identifies a subgroup of patients with lesions that behave like stage III cancers, which may have therapeutic implications in this group of patients.
Journal Article
Selective Toxicity of Rhodamine 123 in Carcinoma Cells in Vitro
TL;DR: It is demonstrated that with continuous exposure, rhodamine 123 selectively kills carcinoma as compared to normal epithelial cells grown in vitro.
Journal Article
Microsatellite Instability in Bladder Cancer
Mirella Gonzalez-Zulueta,J. Michael Ruppert,Kaori Tokino,Yvonne C. Tsai,Charles Spruck,Noriomi Miyao,Peter W. Nichols,Gregers G. Hermann,Thomas Horn,Kenneth Steven,Ian C. Summerhayes,David Sidransky,Peter A. Jones +12 more
TL;DR: Somatic instability at microsatellite repeats was detected in 6 of 200 transitional cell carcinomas of the bladder, suggesting that these alterations can occur early in bladder tumorigenesis.