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Ian R. van Driel
Researcher at University of Melbourne
Publications - 93
Citations - 3432
Ian R. van Driel is an academic researcher from University of Melbourne. The author has contributed to research in topics: Autoimmune Gastritis & T cell. The author has an hindex of 29, co-authored 92 publications receiving 3182 citations. Previous affiliations of Ian R. van Driel include Walter and Eliza Hall Institute of Medical Research & Monash University.
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Journal ArticleDOI
Molecular Pathogenesis of Infections Caused by Legionella pneumophila
TL;DR: The factors that contribute to the ability of L. pneumophila to infect and replicate in human cells and amoebae are reviewed with an emphasis on proteins that are secreted by the bacteria into the Legionella vacuole and/or the host cell.
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NKT cells are phenotypically and functionally diverse.
Kirsten J. L. Hammond,Sonja B. Pelikan,Nadine Y. Crowe,Elise Randle-Barrett,Toshinori Nakayama,Masaru Taniguchi,Mark J. Smyth,Ian R. van Driel,Roland Scollay,Alan G. Baxter,Dale I. Godfrey +10 more
TL;DR: It is shown that NKT cells are phenotypically, functionally and developmentally heterogeneous, and that three distinct subsets (CD4+, DN and CD8+) are differentially distributed in a tissue‐specific fashion.
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Organ-specific autoimmunity induced by lymphopenia.
TL;DR: neonatal thymectomy was shown to induce a wide variety of organ-specific autoimmune diseases in mice, with different strains showing differences in disease susceptibility, and the overlap in autoimmune Diseases in this mouse model is reminiscent of the overlap observed in the endocrine organ/stomach cluster of organ
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IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.
Jan Naujoks,Christoph Tabeling,Brian D. Dill,Christine Hoffmann,Andrew S. Brown,Mareike Kunze,Stefan Kempa,Andrea Peter,Hans-Joachim Mollenkopf,Anca Dorhoi,Olivia Kershaw,Achim D. Gruber,Leif E. Sander,Martin Witzenrath,Susanne Herold,Andreas Nerlich,Andreas C. Hocke,Ian R. van Driel,Norbert Suttorp,Sammy Bedoui,Hubert Hilbi,Hubert Hilbi,Matthias Trost,Bastian Opitz +23 more
TL;DR: It is shown that type I and II IFNs are master regulators of gene expression during Legionella pneumophila infection, and activators of an alveolar macrophage-intrinsic immune response that restricts bacterial growth during pneumonia.
Journal ArticleDOI
Influence of Gastric Acid on Susceptibility to Infection with Ingested Bacterial Pathogens
Sharon M. Tennant,Elizabeth L. Hartland,Elizabeth L. Hartland,Tongted Phumoonna,Dena Lyras,Julian I. Rood,Roy M. Robins-Browne,Ian R. van Driel +7 more
TL;DR: A mouse model is developed to quantify the effectiveness of gastric acid in mediating resistance to infection with ingested bacteria and to investigate the effects of hypochlorhydria on susceptibility to infection and to evaluate the in vivo susceptibility to gastric Acid of orally administered therapies, such as vaccines and probiotics.