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Nadine Y. Crowe
Researcher at Monash University
Publications - 12
Citations - 3298
Nadine Y. Crowe is an academic researcher from Monash University. The author has contributed to research in topics: Natural killer T cell & Interleukin 12. The author has an hindex of 11, co-authored 12 publications receiving 3212 citations. Previous affiliations of Nadine Y. Crowe include University of Melbourne & Alfred Hospital.
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Journal ArticleDOI
Differential tumor surveillance by natural killer (NK) and NKT cells
Mark J. Smyth,Kevin Y. T. Thia,Shayna E. A. Street,Erika Cretney,Joseph A. Trapani,Masaru Taniguchi,Tetsu Kawano,Sonja B. Pelikan,Nadine Y. Crowe,Dale I. Godfrey +9 more
TL;DR: T cell receptor Jα281 gene-targeted mice confirmed a critical function for NKT cells in protection from spontaneous tumors initiated by the chemical carcinogen, methylcholanthrene, which is the first description of an antitumor function in the absence of exogenously administered potent stimulators such as IL-12 or α-galactosylceramide.
Journal ArticleDOI
Sequential production of interferon-gamma by NK1.1(+) T cells and natural killer cells is essential for the antimetastatic effect of alpha-galactosylceramide.
Mark J. Smyth,Nadine Y. Crowe,Daniel G. Pellicci,Konstantinos Kyparissoudis,Jason Kelly,Kazuyoshi Takeda,Hideo Yagita,Dale I. Godfrey +7 more
TL;DR: It was demonstrated that the sequential production of IFN-gamma by NKT cells and NK cells was absolutely required to reconstitute the antimetastatic activity of alpha-GalCer.
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NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma.
TL;DR: The results indicate that both NK cells and NKT cells are essential and collaborate in natural host immunity against MCA-induced sarcoma.
Journal Article
Sequential production of interferon-gamma by NK1.1( ) T cells and natural killer cells is essential for the antimetastatic effect of alpha-galactosylceramide
Mark J. Smyth,Nadine Y. Crowe,Daniel G. Pellicci,Konstantinos Kyparissoudis,Jason Kelly,Kazuyoshi Takeda,Hideo Yagita,Dale I. Godfrey +7 more
TL;DR: In this paper, the antimetastatic effect of the CD1d-binding glycolipid, α-Galactosylceramide (α-GalCer), is mediated by NK1.1+T (NKT) cells; however, the mechanisms behind this process are poorly defined.
Journal ArticleDOI
A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas.
TL;DR: It is demonstrated that, in addition to their importance in tumor immunotherapy induced by IL-12 or α-GalCer, NK T cells can play a critical role in tumor Immunosurveillance, at least against MCA-induced sarcomas, in the absence of exogenous stimulation.