Ignacio Obeso

TL;DR: It is suggested that imbalance between goal-directed and habitual action and inhibition contributes to some manifestations of Parkinson's disease, Tourette syndrome and obsessive–compulsive disorder and is proposed that basal ganglia surgery improves these disorders by restoring a functional balance between facilitation and inhibition.

TL;DR: PD patients were impaired on the conditional stop signal reaction time task, with response initiation both in situations with or without conflict and response inhibition all being significantly delayed, and had significantly greater difficulty in suppressing prepotent or habitual responses on the Stroop, Hayling and random number generation tasks relative to controls.

TL;DR: MRI-guided focused ultrasound unilateral subthalamotomy was well tolerated and seemed to improve motor features of Parkinson's disease in patients with noticeably asymmetric parkinsonism.

TL;DR: A body of evidence supports the role of the STN in inhibitory and executive control in patients with PD, as well as the psychiatric side effects of STN‐DBS.

TL;DR: The results provide direct support for the involvement of the subthalamic nucleus in response inhibition and suggest that this function may be mediated by a specific reduction in gamma oscillations in the cortico-subthalamic connection.