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Ihn Young Song
Researcher at Boston University
Publications - 6
Citations - 333
Ihn Young Song is an academic researcher from Boston University. The author has contributed to research in topics: Proliferating cell nuclear antigen & Chromatin. The author has an hindex of 6, co-authored 6 publications receiving 310 citations.
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Genomic size of CENP-A domain is proportional to total alpha satellite array size at human centromeres and expands in cancer cells
TL;DR: The results suggest that cancer transformation and amounts of centromeric heterochromatin have notable effects on the amount of alpha satellite that is associated with CENP-A chromatin, and imply that alpha satellite array size may be a more prominent predictor of CENp-A incorporation than chromosome size.
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Telomere Disruption Results in Non-Random Formation of De Novo Dicentric Chromosomes Involving Acrocentric Human Chromosomes
Kaitlin M. Stimpson,Ihn Young Song,Anna Jauch,Heidi Holtgreve-Grez,Karen E. Hayden,Joanna M. Bridger,Beth A. Sullivan +6 more
TL;DR: It is demonstrated that transient disruption of human telomere structure non-randomly produces dicentric fusions involving acrocentric chromosomes and a human cell culture model is described that enriches for de novo dicentrics.
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Rad18-mediated translesion synthesis of bulky DNA adducts is coupled to activation of the Fanconi anemia DNA repair pathway.
TL;DR: A novel Rad18-dependent mechanism is demonstrated that couples activation of the FA pathway with TLS and induces DNA damage-independent mono-ubiquitination of proliferating cell nuclear antigen (PCNA) and FANCD2.
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Role of Jade-1 in the Histone Acetyltransferase (HAT) HBO1 Complex
Rebecca L. Foy,Ihn Young Song,Vipul C. Chitalia,Herbert T. Cohen,Nehmé Saksouk,Christelle Cayrou,Cyrus Vaziri,Jacques Côté,Maria V. Panchenko +8 more
TL;DR: It is demonstrated that Jade-1/1L are crucial co-factors for HBO1-mediated histone H4 acetylation in live cells and in vitro with reconstituted oligonucleosome substrates.
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Reduced Expression of GINS Complex Members Induces Hallmarks of Pre-malignancy in Primary Untransformed Human Cells
TL;DR: S-phase progression of untransformed cells containing sub-optimal levels of Psf1/2 is associated with replication stress and acquisition of DNA damage, and the ensuing Chk2-mediated DNA damage signalling likely contributes to maintenance of chromosomal integrity.