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Ilona Staprans
Researcher at University of California, San Francisco
Publications - 42
Citations - 2789
Ilona Staprans is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Chylomicron & Triglyceride. The author has an hindex of 27, co-authored 42 publications receiving 2704 citations. Previous affiliations of Ilona Staprans include United States Department of Veterans Affairs & Veterans Health Administration.
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Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance.
Kenneth R. Feingold,Ilona Staprans,Riaz A. Memon,A H Moser,Judy K. Shigenaga,William T. Doerrler,C A Dinarello,Carl Grunfeld +7 more
TL;DR: The data suggest that neither of these cytokines is absolutely required for the increase in serum triglycerides induced by LPS, raising the possibility that other cytokines, small molecular mediators, or LPS itself may play a crucial role.
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Interleukin-6 stimulates hepatic triglyceride secretion in rats.
Katsunori Nonogaki,Gerald M. Fuller,Nelson L. Fuentes,Arthur H. Moser,Ilona Staprans,Carl Grunfeld,Kenneth R. Feingold +6 more
TL;DR: It is demonstrated that changes in hepatic triglyceride metabolism are another acute phase response that can be induced by IL-6, and the hypertriglyceridemia induced byIL-6 was due to increased secretion by the liver.
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Infection and Inflammation Induce LDL Oxidation In Vivo
Riaz A. Memon,Ilona Staprans,Mustafa A. Noor,Walter M. Holleran,Yoshikazu Uchida,Arthur H. Moser,Kenneth R. Feingold,Carl Grunfeld +7 more
TL;DR: Results demonstrate that the host response to infection and inflammation increases oxidized lipids in serum and induces LDL oxidation in vivo, which may promote atherogenesis and could be a mechanism for increased incidence of coronary artery disease in patients with chronic infections and inflammatory disorders.
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Oxidized lipids in the diet are a source of oxidized lipid in chylomicrons of human serum.
TL;DR: It is demonstrated that in humans dietary oxidized lipids are absorbed by the small intestine, incorporated into chylomicrons, and appear in the bloodstream, where they contribute to the total body pool of oxidized lipid.
Journal ArticleDOI
The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis.
TL;DR: It is hypothesized that diet-derived oxidized fatty acids in chylomicron remnants and oxidized cholesterol in remnants and LDL accelerate atherosclerosis by increasing oxidized lipid levels in circulating LDL and chylomaticron remnants.